When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function as biomarkers for patient-tailored targeting of senescence in OA. Accumulation [...]
A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue before drawing conclusions. Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Hein Putter and Mar Rodríguez-Girondo posted a PubPeer comment (a postpublication [...]
Doe mee aan de gratis mini-cursus ‘Vitaal en gezond ouder worden’ Wat is veroudering eigenlijk? Komt er straks een anti-verouderingspil? Hoeveel moet ik bewegen en wat kan ik het beste eten? In de gratis 8-delige mini-cursus ‘Vitaal en gezond ouder worden’ praten Nederlandse topwetenschappers je bij over de laatste inzichten uit wetenschappelijk onderzoek naar veroudering. De [...]
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress | Osteoarthritis and Cartilage Open| 4(1) (2022) 100231 | doi: 10.1016/j.ocarto.2021.100231 R.G.M. Timmermans, N.G.C. Bloks, M. Tuerlings, M. van Hoolwerff, R.G.H.H. Nelissen, R.J.P. van der Wal, P.M. van der Kraan, A.B. Blom, M.H.J. van den [...]
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis | Hum Mol Genet | 2022 Jan 28:ddac017 | doi: 10.1093/hmg/ddac017. Katsoula G, Steinberg J, Tuerlings M, de Almeida RC, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini E. Abstract Osteoarthritis is a prevalent joint disease and a [...]
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease| Osteoarthritis Cartilage | 2022 Feb 25:S1063-4584(22)00650-1 | doi: 10.1016/j.joca.2022.02.615 Monteagudo S, Cornelis FMF, Wang X, de Roover A, Peeters T, Quintiens J, Sermon A, de Almeida RC, Meulenbelt I, Lories RJ Summary Objectives To investigate how ANP32A, previously linked to the antioxidant [...]
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Rheumatology (Oxford)| 2022 Apr 5:keac202 | doi: 10.1093/rheumatology/keac202 Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Abstract Objectives [...]
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization Rheumatology (Oxford) | 2022 Apr 12:keac232 | doi: 10.1093/rheumatology/keac232 Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, Freund C, Mummery C, Everts V, de Vries TJ, Ramos [...]
The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) | 2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]
Onderzoekers kunnen aan de hand van de afstelling van het DNA nauwkeurig vaststellen hoe oud iemand is. Daarvoor gebruiken ze een zogeheten epigenetische klok. Masterstudent Thomas Jonkman heeft nu, negen jaar na de ontdekking, ontrafeld hoe deze klok precies werkt: het blijkt de veroudering van ons immuunsysteem bij te houden. Met deze kennis kan [...]
