Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from 7 time points during a 49-day chondrogenic hiPSC differentiation protocol using single-nucleus multimodal [...]
Nickel Maunu M, Meulenbelt I, Ramos YFM | 22-07-2026 | Stem cells are key for development of disease modeling and therapies. While promising, however, current application of cutting-edge hiPSC technologies is, among others, confounded by cellular heterogeneity leading to concerns about their suitability for experimental and clinical applications. Variations across donors, tissue sources, methodologies, [...]
Giorgia Mazzini, Margo Tuerlings,[...], and Ingrid Meulenbelt | 08-06-2026 | Cell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production by hiPSC-derived chondroprogenitors (hiCPCs), their derived chondrocytes (hiCHOs), and primary articular chondrocytes (hACs) [...]
Swier Garst,[...], P Eline Slagboom, Joyce van Meurs | 18-05-2026 | Because individuals age at different rates, robust aging biomarkers are needed beyond chronological age. However, the methodological choices that shape such biomarkers have not been compared in a unified framework. This study addresses that gap by evaluating model choice, training targets, and protein [...]
Bogaards FA, Groenendijk I, [...], Slagboom PE | 17-04-2026 | Nutritional weight-loss interventions are known to reduce bone mineral density (BMD), which can be prevented by adding (resistance) exercise training. However, this combined effect is not well studied in non-obese adults. In addition, the association between biomarkers and metabolite-based composite health markers with changes [...]
INVITATION: MOLEPI Symposium In celebration of our 25th ANNIVERSARY, we WILL BE hosting a special symposium to reflect on our journey and explore the future of molecular epidemiology 📅 THURSDAY, OCTOBER 30, 2025 ⌚ 13:30 – 18:00 📍 LUMC, BUILDING 1, LECTURE HALL 1 Let’s celebrate! Sign up here: https://forms.lumc.nl/lumc2/MOLEPI_symposium_2025 Preliminary program: [...]
Invitation: MOLEPI reunion 2025 We will be hosting a reunion for all our former and present colleagues over the past 25 years 📅 SATURDAY NOVEMBER 1, 2025 ⌚ 14:00 – 18:00 📍 LUMC, BUILDING 2, The Restaurant Let’s celebrate! Sign up here: https://forms.lumc.nl/lumc2/MOLEPI_Reunion_2025 The program will be announced later! [...]
Eline Slagboom is opzoek naar nieuwe langlevende families Leidse onderzoekers Eline Slagboom en Niels van den Berg doen onderzoek naar factoren die bijdragen aan een gezond en langer gezond leven, en zij zijn op zoek naar nieuwe langlevende families. Geschikte kandidaten zijn mensen van 75 jaar of ouder die nog een broer of [...]
Associatie gevonden tussen depressieve symptomen en plasma markers voor de ziekte van Alzheimer Het Nederlands Consortium of Dementie Cohorten heeft een meta-analyse gedaan met 8 cohort studies om te onderzoeken of plasma markers voor Alzheimer en neurodegeneratie associëren met depressieve symptomen later in het leven. De Leiden LangLeven Studie was één van [...]
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact well-being. On the other hand, plant-based diets have been found [...]
