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The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study
M Tuerlings, YFM Ramos, HED Suchiman, S Sayedipour, SD Joustra, A Rabelink-Hoogenstraaten, HA van Duyvenvoorde, DRJ Kempink, PB de Witte, I Meulenbelt, C de Bruin | 25-08-2026 | The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study. ABSTRACT Background Viable pediatric human growth plate (GP) tissue is rarely [...]
Nuclear Factor I genes drive chondrogenic cell-fate commitment
Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from 7 time points during a 49-day chondrogenic hiPSC differentiation protocol using single-nucleus multimodal [...]
