LAATSTE NIEUWS
A word of caution on the regression to the mean phenomenon in (biological) age prediction
A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue before drawing conclusions. Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Hein Putter and Mar Rodríguez-Girondo posted a PubPeer comment (a postpublication [...]
Doe mee aan de gratis mini-cursus ‘Vitaal en gezond ouder worden’
Doe mee aan de gratis mini-cursus ‘Vitaal en gezond ouder worden’ Wat is veroudering eigenlijk? Komt er straks een anti-verouderingspil? Hoeveel moet ik bewegen en wat kan ik het beste eten? In de gratis 8-delige mini-cursus ‘Vitaal en gezond ouder worden’ praten Nederlandse topwetenschappers je bij over de laatste inzichten uit wetenschappelijk onderzoek naar veroudering. De [...]
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress | Osteoarthritis and Cartilage Open| 4(1) (2022) 100231 | doi: 10.1016/j.ocarto.2021.100231 R.G.M. Timmermans, N.G.C. Bloks, M. Tuerlings, M. van Hoolwerff, R.G.H.H. Nelissen, R.J.P. van der Wal, P.M. van der Kraan, A.B. Blom, M.H.J. van den [...]
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis | Hum Mol Genet | 2022 Jan 28:ddac017 | doi: 10.1093/hmg/ddac017. Katsoula G, Steinberg J, Tuerlings M, de Almeida RC, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini E. Abstract Osteoarthritis is a prevalent joint disease and a [...]
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease.
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease| Osteoarthritis Cartilage | 2022 Feb 25:S1063-4584(22)00650-1 | doi: 10.1016/j.joca.2022.02.615 Monteagudo S, Cornelis FMF, Wang X, de Roover A, Peeters T, Quintiens J, Sermon A, de Almeida RC, Meulenbelt I, Lories RJ Summary Objectives To investigate how ANP32A, previously linked to the antioxidant [...]
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Rheumatology (Oxford)| 2022 Apr 5:keac202 | doi: 10.1093/rheumatology/keac202 Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Abstract Objectives [...]