Proefschriften Artrose2021-09-13T12:00:02+00:00

Proefschriften Artrose

Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis

Evelyn Houtman | 22-10-2022 | Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis This thesis aims to increase the understanding of human osteoarthritis pathophysiology by developing reliable biomimetic ex vivo human osteochondral explant models and focussing on the [...]

november 22nd, 2023|Categories: proefschrift artrose|

Osteoprotegerin: a double-edged sword in osteoarthritis development

Alejandro Rodríguez Ruiz | 22-09-2022 | Osteoprotegerin: a double-edged sword in osteoarthritis development To advance development of effective disease modifying OA treatments, a better understanding of its pathophysiological mechanisms is necessary. By studyinga family with early onset OA and high cartilage mineralization, a likely [...]

november 22nd, 2023|Categories: proefschrift artrose|

The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy

Margo Tuerlings | 27-09-2023 | The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy. Osteoarthritis (OA) is a prevalent age-related joint disease, determined by diverse changes in pathways maintaining articular cartilage and subchondral bone. This thesis aimed to identify and study [...]

november 21st, 2023|Categories: proefschrift artrose|

Dissecting cellular function of fibronectin in osteoarthritic cartilage

Marcella van Hoolwerff | 06-09-2022 | Dissecting cellular function of fibronectin in osteoarthritic cartilage The aim of this thesis was to combine transcriptomics, genetics and human disease modelling to obtain further insight into molecular processes underlying osteoarthritis. More specifically, we aimed to elucidate the [...]

november 21st, 2023|Categories: proefschrift artrose|

Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe [...]

juli 5th, 2021|Categories: proefschrift artrose|

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose [...]

juli 5th, 2021|Categories: proefschrift artrose|
Ga naar de bovenkant