DECEMBER

Frkatović-Hodžić A, Mijakovac A, Miškec K, Nostaeva A, Sharapov SZ, Landini A, Haller T, Akker EVD, Sharma S, Cuadrat RRC, Mangino M, Li Y, Keser T, Rudman N, Štambuk T, Pučić-Baković M, Trbojević-Akmačić I, Gudelj I, Štambuk J, Pribić T, Radovani B, Tominac P, Fischer K, Beekman M, Wuhrer M, Gieger C, Schulze MB, Wittenbecher C, Polasek O, Hayward C, Wilson JF, Spector TD, Köttgen A, Vučković F, Aulchenko YS, Vojta A, Krištić J, Klarić L, Zoldoš V, Lauc G. Mapping of the gene network that regulates glycan clock of ageing. Aging (Albany NY). 2023 Dec 26;15(24):14509-14552. doi: 10.18632/aging.205106.

NOVEMBER

Cheng M, Conley D, Kuipers T, Li C, Ryan C, Taubert J, Wang S, Wang T, Zhou J, Schmitz LL, Tobi EW, Heijmans B, Lumey LH, Belsky DW. Accelerated biological aging six decades after prenatal famine exposure. medRxiv. 2023 Nov 4:2023.11.03.23298046. doi: 10.1101/2023.11.03.23298046.

Bizzarri D, Reinders MJT, Beekman M, Slagboom PE, van den Akker EB, On Behalf Of The BBMRINL. Technical Report: A Comprehensive Comparison between Different Quantification Versions of Nightingale Health’s 1H-NMR Metabolomics Platform. Metabolites. 2023 Nov 30;13(12):1181. doi: 10.3390/metabo13121181.

OKTOBER

Kuiper LM, Polinder-Bos HA, Bizzarri D, Vojinovic D, Vallerga CL, Beekman M, Dollé ET, Ghanbari M, Voortman T, Reinders MJT, Verschuren WMM, Slagboom PE, van den Akker EB, van Meurs JBJ. Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk. J Gerontol A Biol Sci Med Sci. 2023 Oct 9;78(10):1753-1762. doi: 10.1093/gerona/glad137

Costeira R, Evangelista L, Wilson R, Yan X, Hellbach F, Sinke L, Christiansen C, Villicaña S, Masachs OM, Tsai PC, Mangino M, Menni C, Berry SE, Beekman M, van Heemst D, Slagboom PE, Heijmans BT, Suhre K, Kastenmüller G, Gieger C, Peters A, Small KS, Linseisen J, Waldenberger M, Bell JT. Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome. Clin Epigenetics. 2023 Oct 19;15(1):166. doi: 10.1186/s13148-023-01578-7

Zhou J, Indik CE, Kuipers TB, Li C, Nivard MG, Ryan CP, Tucker-Drob EM, Taeubert MJ, Wang S, Wang T, Conley D, Heijmans BT, Lumey LH, Belsky DW. Genetic analysis of selection bias in a natural experiment: Investigating in-utero famine effects on elevated body mass index in the Dutch Hunger Winter Families Study. medRxiv. 2023 Oct 24:2023.10.23.23297381. doi: 10.1101/2023.10.23.23297381

Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O’Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL. Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. Nat Genet. 2023 Oct;55(10):1651-1664. doi: 10.1038/s41588-023-01518-4.

Todtenhaupt P, Franken LA, Groene SG, van Hoolwerff M, van der Meeren LE, van Klink JMM, Roest AAW, de Bruin C, Ramos YFM, Haak MC, Lopriore E, Heijmans BT, van Pel M. A robust and standardized method to isolate and expand mesenchymal stromal cells from human umbilical cord. Cytotherapy. 2023 Oct;25(10):1057-1068. doi: 10.1016/j.jcyt.2023.07.004.

SEPTEMBER

van Holstein Y, van den Berkmortel PJE, Trompet S, van Heemst D, van den Bos F, Roemeling-van Rhijn M, de Glas NA, Beekman M, Slagboom PE, Portielje JEA, Mooijaart SP, van Munster BC. The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review. J Geriatr Oncol. 2023 Sep;14(7):101567. doi: 10.1016/j.jgo.2023.101567.

Kochlik B, Herpich C, Moreno-Villanueva M, Klaus S, Müller-Werdan U, Weinberger B, Fiegl S, Toussaint O, Debacq-Chainiaux F, Schön C, Bernhard J, Breusing N, Gonos ES, Franceschi C, Capri M, Sikora E, Hervonen A, Hurme M, Slagboom PE, Dollé MET, Jansen E, Grune T, Bürkle A, Norman K. Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study. Geroscience. 2023 Sep 16. doi: 10.1007/s11357-023-00902-6.

AUGUSTUS

Liu Y, Sinke L, Jonkman TH, Slieker RC; BIOS Consortium; van Zwet EW, Daxinger L, Heijmans BT. The inactive X chromosome accumulates widespread epigenetic variability with age. Clin Epigenetics. 2023 Aug 25;15(1):135. doi: 10.1186/s13148-023-01549-y

van Dongen J, Willemsen G; BIOS Consortium; de Geus EJC, Boomsma DI, Neale MC. Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs. Elife. 2023 Aug 10;12:e83286. doi: 10.7554/eLife.83286

Groene SG, Gremmen IJ, van Zwet EW, Roest AAW, Haak MC, van Klink JMM, Lopriore E, Heijmans BT, de Bruin C.     Fetal growth restriction inhibits childhood growth despite catch-up in discordant identical twins: an observational cohort study. Eur J Endocrinol. 2023 Aug 2;189(2):183-189. doi: 10.1093/ejendo/lvad103

JULI

van den Berg N, Rodríguez-Girondo M, van Dijk IK, Slagboom PE, Beekman M. Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles. Nat Commun. 2023 Jul 27;14(1):4518. doi: 10.1038/s41467-023-40245-6

Walton E, Baltramonaityte V, Calhoun V, Heijmans BT, Thompson PM, Cecil CAM. A systematic review of neuroimaging epigenetic research: calling for an increased focus on development. Mol Psychiatry. 2023 Jul;28(7):2839-2847. doi: 10.1038/s41380-023-02067-2

JUNI

Giacconi R, Laffon B, Costa S, Teixeira-Gomes A, Maggi F, Macera L, Spezia PG, Piacenza F, Bürkle A, Moreno-Villanueva M, Bonassi S, Valdiglesias V, Teixeira JP, Dollé MET, Rietman ML, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Weinberger B, Sikora E, Stuetz W, Toussaint O, Debacq-Chainiaux F, Hervonen A, Hurme M, Slagboom PE, Schön C, Bernhardt J, Breusing N, Pásaro E, Maseda A, Lorenzo-López L, Millán-Calenti JC, Provinciali M, Malavolta M. Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts. Gerontology. 2023;69(6):684-693. doi: 10.1159/000528169

MEI

APRIL

Coutinho de Almeida R, Tuerlings M, Ramos Y, Den Hollander W, Suchiman E, Lakenberg N, Nelissen RGHH, Mei H, Meulenbelt I. Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis. Rheumatology (Oxford). 2023 Apr 3;62(4):1669-1676. doi: 10.1093/rheumatology/keac498

Hellbach F, Sinke L, Costeira R, Baumeister SE, Beekman M, Louca P, Leeming ER, Mompeo O, Berry S, Wilson R, Wawro N, Freuer D, Hauner H, Peters A, Winkelmann J, Koenig W, Meisinger C, Waldenberger M, Heijmans BT, Slagboom PE, Bell JT, Linseisen J. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS. Eur J Nutr. 2023 Apr;62(3):1357-1375. doi: 10.1007/s00394-022-03074-9.

MAART

Weihs A, Chaker L, Martin TC, Braun KVE, Campbell PJ, Cox SR, Fornage M, Gieger C, Grabe HJ, Grallert H, Harris SE, Kühnel B, Marioni RE, Martin NG, McCartney DL, McRae AF, Meisinger C, van Meurs JBJ, Nano J, Nauck M, Peters A, Prokisch H, Roden M, Selvin E, Beekman M, van Heemst D, Slagboom EP, Swenson BR, Tin A, Tsai PC, Uitterlinden A, Visser WE, Völzke H, Waldenberger M, Walsh JP, Köttgen A, Wilson SG, Peeters RP, Bell JT, Medici M, Teumer A. Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9. Thyroid. 2023 Mar;33(3):301-311. doi: 10.1089/thy.2022.0373.

Timmermans RGM, Blom AB, Bloks NGC, Nelissen RGHH, van der Linden EHMJ, van der Kraan PM, Meulenbelt I, Ramos YFM, van den Bosch MHJ. CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes. Cartilage. 2023 Mar;14(1):67-75. doi: 10.1177/19476035221144747.

FEBRUARI

Kananen L, Hurme M, Bürkle A, Moreno-Villanueva M, Bernhardt J, Debacq-Chainiaux F, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom E, Talbot D, Libert C, Raitanen J, Koskinen S, Härkänen T, Stenholm S, Ala-Korpela M, Lehtimäki T, Raitakari OT, Ukkola O, Kähönen M, Jylhä M, Jylhävä J. Circulating cell-free DNA in health and disease – the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2023 Feb;45(1):85-103. doi: 10.1007/s11357-022-00590-8.

van Hoolwerff M, Tuerlings M, Wijnen IJL, Suchiman HED, Cats D, Mei H, Nelissen RGHH, van der Linden-van der Zwaag HMJ, Ramos YFM, Coutinho de Almeida R, Meulenbelt I. Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants. Rheumatology (Oxford). 2023 Feb 1;62(2):894-904. doi: 10.1093/rheumatology/keac272

Dekkers KF, Slieker RC, Ioan-Facsinay A, van Iterson M; BIOS consortium; Ikram MA, van Greevenbroek MMJ, Veldink JH, Franke L, Boomsma DI, Slagboom PE, Jukema JW, Heijmans BT. Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response. Nat Commun. 2023 Feb 1;14(1):544. doi: 10.1038/s41467-022-35663-x.

JANUARI

Giacconi R, D’Aquila P, Malavolta M, Piacenza F, Bürkle A, Villanueva MM, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Gradinaru D, Grubeck-Loebenstein B, Sikora E, Stuetz W, Weber D, Toussaint O, Debacq-Chainiaux F, Hervonen A, Hurme M, Slagboom PE, Schön C, Bernhardt J, Breusing N, Duncan T, Passarino G, Bellizzi D, Provinciali M. Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):42-50. doi: 10.1093/gerona/glac154.

Tuerlings M, Janssen GMC, Boone I, van Hoolwerff M, Rodriguez Ruiz A, Houtman E, Suchiman HED, van der Wal RJP, Nelissen RGHH, Coutinho de Almeida R, van Veelen PA, Ramos YFM, Meulenbelt I. WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes. Osteoarthritis Cartilage. 2023 Jan;31(1):39-48. doi: 10.1016/j.joca.2022.09.009.