Publicaties Artrose
The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study
M Tuerlings, YFM Ramos, HED Suchiman, S Sayedipour, SD Joustra, A Rabelink-Hoogenstraaten, HA van Duyvenvoorde, DRJ Kempink, PB de Witte, I Meulenbelt, C de Bruin | 25-08-2026 | The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study. ABSTRACT [...]
Nuclear Factor I genes drive chondrogenic cell-fate commitment
Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from 7 time points [...]
Application of human induced pluripotent stem cells for tissue modeling and therapy: are we on track?
Nickel Maunu M, Meulenbelt I, Ramos YFM | 22-07-2026 | Stem cells are key for development of disease modeling and therapies. While promising, however, current application of cutting-edge hiPSC technologies is, among others, confounded by cellular heterogeneity leading to concerns about their suitability for [...]
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection GalleryComparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Giorgia Mazzini, Margo Tuerlings,[...], and Ingrid Meulenbelt | 08-06-2026 | Cell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production by hiPSC-derived chondroprogenitors [...]
Translational genomics of osteoarthritis in 1,962,069 individuals
Translational genomics of osteoarthritis in 1,962,069 individuals| May 2025 | Nature 641, pages1217–1224 K Hatzikotoulas, L Southam, L Stefansdottir, CG Boer, M-L McDonald, JP Pett, Y-C Park, M Tuerlings, R Mulders, … K Stefansson, I Meulenbelt, SA Teichmann, JBJ van Meurs, U Styrkarsdottir, E [...]
The role of DNA methylation in chondrogenesis of hiPSCs as a stable marker of cartilage quality
G Hajmousa, R Coutinho de Almeida, N Bloks, AR Rodríguez Ruiz , M Bouma, R Slieker, TB Kuipers, RGHH Nelissen, K Ito, C Freund, YFM Ramos, I Meulenbelt | 15-10-2024 | Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals [...]