Publicaties Artrose
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function [...]
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress | Osteoarthritis and Cartilage Open| 4(1) (2022) 100231 | doi: 10.1016/j.ocarto.2021.100231 R.G.M. Timmermans, N.G.C. Bloks, M. Tuerlings, M. van Hoolwerff, R.G.H.H. Nelissen, R.J.P. van der [...]
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis | Hum Mol Genet | 2022 Jan 28:ddac017 | doi: 10.1093/hmg/ddac017. Katsoula G, Steinberg J, Tuerlings M, de Almeida RC, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini [...]
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease.
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease| Osteoarthritis Cartilage | 2022 Feb 25:S1063-4584(22)00650-1 | doi: 10.1016/j.joca.2022.02.615 Monteagudo S, Cornelis FMF, Wang X, de Roover A, Peeters T, Quintiens J, Sermon A, de Almeida RC, Meulenbelt I, Lories RJ [...]
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Rheumatology (Oxford)| 2022 Apr 5:keac202 | doi: 10.1093/rheumatology/keac202 Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, [...]
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization Rheumatology (Oxford) | 2022 Apr 12:keac232 | doi: 10.1093/rheumatology/keac232 Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, [...]