Publicaties artrose2021-09-22T06:01:58+00:00

Publicaties Artrose

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, [...]

november 9th, 2021|Categories: Nieuws, Papers artrose|

Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid [...]

november 9th, 2021|Categories: Nieuws, Papers artrose|

Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state

Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this [...]

november 9th, 2021|Categories: Nieuws, Papers artrose|

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis  AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. [...]

oktober 14th, 2021|Categories: Papers artrose|

Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis

Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis | August 2021 | The Journal of Pathology Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter Ten Dijke  Abstract Chondrocytes in mice developing osteoarthritis [...]

september 21st, 2021|Categories: Papers artrose|

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets | May 2021 | Arthritis Rheumatology Margo Tuerlings, Marcella van Hoolwerff, Evelyn Houtman, Eka H E D Suchiman, Nico Lakenberg, Hailiang Mei, Enrike H M J [...]

september 21st, 2021|Categories: Papers artrose, Papers artrose|
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