Papers Osteoarthritis
The role of TNFRSF11B in development of osteoarthritic cartilage.
The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) | 2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease [...]
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, [...]
Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state
Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations |September 2021 |Cell Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida,........., Rob R G H H Nelissen, Margo Tuerlings, arcOGEN Consortium,.................., Ingrid Meulenbelt , Ming Ta Michael Lee, Joyce B J van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini Abstract Osteoarthritis affects [...]
Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis
Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis | August 2021 | The Journal of Pathology Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter Ten Dijke Abstract Chondrocytes in mice developing osteoarthritis [...]