New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients

When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function as biomarkers for patient-tailored targeting of senescence in OA. Accumulation [...]

By |2023-11-22T08:13:34+00:00November 22nd, 2023|News, Papers artrose|0 Comments

The role of TNFRSF11B in development of osteoarthritic cartilage.

The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) |  2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]

By |2022-04-19T11:06:43+00:00April 19th, 2022|News, Papers artrose|0 Comments

Leiden master’s student cracks epigenetic clock that predicts age – newsitem LUMC 14-01-2022

Researchers can accurately determine how old a person is based on the calibration of the DNA. To do this, they use a so-called epigenetic clock. Master's student Thomas Jonkman has now, nine years after the discovery, unravelled how this clock exactly works: it turns out to keep track of the ageing of our immune [...]

By |2022-01-17T08:47:57+00:00January 17th, 2022|News, News|0 Comments

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman i. Koning, Carolina r. Jost, Aat a. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]

By |2023-11-21T12:11:29+00:00November 9th, 2021|News, Papers artrose|0 Comments

Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state

Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this mutation in an in vitro OA disease model using human [...]

By |2021-11-09T09:47:44+00:00November 9th, 2021|News, News, Papers artrose, Papers artrose|0 Comments

Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

By |2021-10-19T12:49:11+00:00October 19th, 2021|News, Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

By |2021-10-11T13:56:10+00:00October 11th, 2021|News, Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | October 2021 |American Diabetes Association Sofia Thomaidou, Roderick C. Slieker, Arno R. van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M. ‘t Hart, Bobby Koeleman, Françoise Carlotti, Rob C. Hoeben, Bart O. Roep, Hailiang Mei and Arnaud [...]

By |2021-11-09T13:18:49+00:00October 9th, 2021|News, papers SASC|0 Comments

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations |September 2021 |Cell Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida,........., Rob R G H H Nelissen, Margo Tuerlings, arcOGEN Consortium,.................., Ingrid Meulenbelt  , Ming Ta Michael Lee, Joyce B J van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini Abstract Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide [...]

By |2021-09-21T12:27:49+00:00September 21st, 2021|News, Papers artrose|0 Comments

How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

By |2021-11-09T13:19:14+00:00September 19th, 2021|News, Papers artrose|0 Comments
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