High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]

By |2022-01-04T10:00:58+00:00November 9th, 2021|News, Papers artrose|0 Comments

Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

By |2021-10-19T12:49:11+00:00October 19th, 2021|News, Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

By |2021-10-11T13:56:10+00:00October 11th, 2021|News, Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | October 2021 |American Diabetes Association Sofia Thomaidou, Roderick C. Slieker, Arno R. van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M. ‘t Hart, Bobby Koeleman, Françoise Carlotti, Rob C. Hoeben, Bart O. Roep, Hailiang Mei and Arnaud [...]

By |2021-11-09T13:18:49+00:00October 9th, 2021|News, papers SASC|0 Comments

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations |September 2021 |Cell Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida,........., Rob R G H H Nelissen, Margo Tuerlings, arcOGEN Consortium,.................., Ingrid Meulenbelt  , Ming Ta Michael Lee, Joyce B J van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini Abstract Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide [...]

By |2021-09-21T12:27:49+00:00September 21st, 2021|News, Papers artrose|0 Comments

How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

By |2021-11-09T13:19:14+00:00September 19th, 2021|News, Papers artrose|0 Comments

De eerste 1.000 dagen beïnvloeden het hele leven – NRC augustus 2021

NRC | 20 augustus 2021 | auteur Niki Korteweg Gezonde kinderen Een slechte start in de eerste duizend dagen na de conceptie zet een kind een leven lang op achterstand. Veel risicofactoren gaan samen: roken, drinken, stress… „Maar jonge kinderen hebben een enorme veerkracht.”\ Lees het artikel op de website van het NRC [...]

By |2021-09-21T12:36:04+00:00August 25th, 2021|News|0 Comments

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida & Ingrid Meulenbelt Background Failing of intrinsic [...]

By |2021-11-09T11:57:40+00:00August 15th, 2021|News, Papers artrose|0 Comments

Nature Reviews Cardiology publication about T cells in atherosclerosis

Nature Reviews Cardiology publiceerde een artikel over het effect van vetzuren op T cellen en de implicaties voor atherosclerose onder leiding van LUMC-onderzoekers Wouter Jukema (Cardiologie) en Bas Heijmans (Biomedische Datawetenschappen). ‘Het is hoog tijd voor meer aandacht voor T cellen in cardiovasculair onderzoek, want atherosclerotische plaques zitten vol onstekings en T cellen [...]

By |2021-09-21T12:36:27+00:00July 20th, 2021|News, review|0 Comments

Prestigious ZonMw Open Competition grant awarded to LUMC, VU and RIVM

Prestigious ZonMw Open Competition grant awarded to LUMC, Vu and RIVM Our life expectancy is increasing worldwide, but the years we spend in good health are lagging behind. People from long-lived families often reach exceptionally old ages without disease. How is that possible? A multidisciplinary research team from the LUMC, the VU [...]

By |2021-07-20T08:44:59+00:00June 29th, 2021|News|0 Comments
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