Bio informatics

Bioinformatics is a field that focuses on devising and developing new methods at the interface of informatics and statistics that help us increase our understanding of biological processes. For example, new calculation methods are being developed for discovering interesting patterns and properties in large amounts of biological data in cohort studies.

Challenges

The large amount of data collected in contemporary biological research, such as sequencing data and data on metabolites, offers great opportunities, but also challenges. For example, it requires innovative methods to process this data with a workable amount of computing time and computer memory. Moreover, it involves measurements of a large number of different biological factors, all of which are related in a different, complex way to processes such as aging, which makes finding these connections a complex task.

Calculation Methods

To this end, we have developed calculation methods to find structural variants: changes to the DNA or RNA, such as duplicates. These structural variants may play a role in several disease processes. In addition, we have developed methods that allow researchers to compare biological sequences in a consistent manner. This has been incorporated into the mutalizer website, where researchers can have such descriptions generated.

Classification and models

We are also working on classification and clustering models in which different types of information are brought together to try to estimate the probability that someone with a certain biological profile will develop a disease. For example, we focus on so-called “semi-supervised” models, where additional information is available in the form of partially observed data points.

Sequencing Analysis Support Core

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Leiden Computional Biology Center

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BIO INFORMATICS TEAM

Prof.dr.ir. Marcel Reinders – LCBC

Professor and staff member

dr. Eric van den Akker – LCBC

Assistant professor

Onur Karakaslar – LCBC

Phd-student – LCBC

Jeppe Severens – LCBC

Phd-student – LCBC

dr. Leon Mei – SASC

Manager

Ruben Vorderman – SASC

Application developer

Ioannis Moustakas -SASC

Research analist

Jasper Boom – SASC

Research analist

Davy Cats – SASC

Research analist

Tom Kuipers – SASC

Research analist

Cedrick Agaser – SASC

Research analist

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