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How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

By |2021-10-19T12:48:57+00:00October 19th, 2021|News, Papers artrose|0 Comments

Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

By |2021-10-19T12:49:11+00:00October 19th, 2021|News, Papers ageing|0 Comments

Improved selection of participants in genetic longevity studies: family scores revisited

Improved selection of participants in genetic longevity studies: family scores revisited | BMC Medicine | January 2021 Rodriguez-Girondo, M.; Berg, N. van den; Hof, M.H.; Beekman, M.; Slagboom, E. Background: Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited [...]

By |2021-10-11T13:53:07+00:00October 11th, 2021|Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

By |2021-10-11T13:56:10+00:00October 11th, 2021|News, Papers ageing|0 Comments

Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls

Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls |  Clin exp Rheumothol | May/June 2021 Marije K Verheul, George M C Janssen, Arnoud de Ru, Gerrie Stoeken-Rijsbergen, E W Nivine Levarht, Joanneke C Kwekkeboom, Nils Bomer, Andreea Ioan-Facsinay, Ingrid Meulenbelt, Robert A Cordfunke, Jan W Drijfhout, Rene E M Toes, Peter A van Veelen, Leendert A Trouw Abstract Objectives: Antibodies targeting [...]

By |2021-10-11T13:35:15+00:00October 11th, 2021|Papers artrose|0 Comments

Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study

Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study | Diabetes| August 2021 | Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi [...]

By |2021-10-11T13:56:29+00:00October 11th, 2021|Papers ageing|0 Comments

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients | EMBO Mol Med | April 2021 Mirko Signorelli, Mitra Ebrahimpoor, Olga Veth, Kristina Hettne, Nisha Verwey, Raquel García-Rodríguez,  Christa L Tanganyika-deWinter, Luz B Lopez Hernandez, Rosa Escobar Cedillo, Benjamín Gómez Díaz, Olafur T Magnusson, Hailiang Mei, Roula Tsonaka, Annemieke Aartsma-Rus, Pietro Spitali Abstract DMD is a rare disorder characterized by progressive muscle degeneration and [...]

By |2021-10-11T12:47:34+00:00October 11th, 2021|paper bioinformatica, Papers ageing|0 Comments

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells | Genome Med | 2021 Mar 24 Shadi Darvish Shafighi, Szymon M Kiełbasa, Julieta Sepúlveda-Yáñez, Ramin Monajemi,  Davy Cats, Hailiang Mei, Roberta Menafra, Susan Kloet, Hendrik Veelken,  Cornelis A M van Bergen, Ewa Szczurek  Abstract Background: Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. [...]

By |2021-10-11T13:57:18+00:00October 11th, 2021|paper bioinformatica|0 Comments

Cingulate networks associated with gray matter loss in Parkinson’s disease show high expression of cholinergic genes in the healthy brain

Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain | Eur J Neurosci | June 2021 Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D J van de Berg, Jacobus J van Hilten,  Marcel J T Reinders, Ahmed Mahfouz  Abstract Structural covariance networks are able to identify [...]

By |2021-10-11T13:57:35+00:00October 11th, 2021|paper bioinformatica|0 Comments

CBA: Cluster-Guided Batch Alignment for Single Cell RNA-seq

CBA: Cluster-Guided Batch Alignment for Single Cell RNA-seq | April 2021 | Frontiers in Genetics |DOI:10.3389/fgene.2021.644211 Wenbo Yu, Ahmed Mahfouz, Marcel J.T. Reinders Abstract and Figures The power of single-cell RNA sequencing (scRNA-seq) in detecting cell heterogeneity or developmental process is becoming more and more evident every day. The granularity of this knowledge is further propelled [...]

By |2021-10-11T13:57:48+00:00October 11th, 2021|paper bioinformatica|0 Comments
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