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Depressive symptoms and plasma markers of Alzheimer’s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies

Depressive symptoms and plasma markers of Alzheimer's disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and plasma markers for Alzheimer’s disease and neurodegeneration. The Leiden Longevity [...]

By |2024-03-18T15:55:23+00:00March 18th, 2024|News|0 Comments
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Healthful plant-based diet associates with greater well-being in older adults

A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact well-being. On the other hand, plant-based diets have been found [...]

By |2024-03-18T15:57:00+00:00February 19th, 2024|News, Papers ageing|0 Comments
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Leiden master’s student cracks epigenetic clock that predicts age – newsitem LUMC 14-01-2022

Researchers can accurately determine how old a person is based on the calibration of the DNA. To do this, they use a so-called epigenetic clock. Master's student Thomas Jonkman has now, nine years after the discovery, unravelled how this clock exactly works: it turns out to keep track of the ageing of our immune [...]

By |2022-01-17T08:47:57+00:00January 17th, 2022|News, News|0 Comments
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High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman i. Koning, Carolina r. Jost, Aat a. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]

By |2023-11-21T12:11:29+00:00November 9th, 2021|News, Papers artrose|0 Comments
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Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt Abstract Objective To gain insight in the expression profile [...]

By |2021-11-09T13:18:07+00:00November 9th, 2021|News, Papers artrose|0 Comments
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Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

By |2021-10-19T12:49:11+00:00October 19th, 2021|News, Papers ageing|0 Comments
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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis  AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 [...]

By |2021-11-09T13:18:29+00:00October 14th, 2021|Papers artrose|0 Comments
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Improved selection of participants in genetic longevity studies: family scores revisited

Improved selection of participants in genetic longevity studies: family scores revisited | BMC Medicine | January 2021 Rodriguez-Girondo, M.; Berg, N. van den; Hof, M.H.; Beekman, M.; Slagboom, E. Background: Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited [...]

By |2021-10-11T13:53:07+00:00October 11th, 2021|Papers ageing|0 Comments
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Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

By |2021-10-11T13:56:10+00:00October 11th, 2021|News, Papers ageing|0 Comments
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Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study

Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study | Diabetes| August 2021 | Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi [...]

By |2021-10-11T13:56:29+00:00October 11th, 2021|Papers ageing|0 Comments
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Moleculaire Epidemiologie  | copyright 2021

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