Koen Dekkers | 16-01-2025 | Effects of lipids on DNA methylation and gene expression of immune cells implicated in atherosclerosis Cardiovascular diseases, the leading cause of death worldwide, are often the result of atherosclerosis, a chronic inflammatory disease where lipids and immune cells accumulate [...]

Pia Todtenhaupt | 18-12-2024 | Unravelling the developmental origins of disease: the power of mesenchymal stromal cells and monochorionic twins This thesis explores the mechanisms linking adverse intrauterine environments to long-term health risks. Therefore, the Twinlife study was established. This study includes monochorionic (MC) twins [...]

Nathalie Reilly | 30-10-2024 | The effects of triglycerides and fatty acids on T cells: role in atherosclerosis Atherosclerosis, a leading cause of cardiovascular disease, is characterized by lipid accumulation in blood vessel walls. This chronic inflammation leads to plaque formation, increasing the risk [...]

Rudolf Talens | 08-01-2015 |Studies into epigenetic variation and its contribution to cardiovascular disease  Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully transmitted during mitosis and are generally stable in differentiated cells, [...]

Elmar Tobi | 29-10-2013 | Epigenetic differences after prenatal adversity: The Dutch Hunger Winter This thesis is a study on the link between early development and adult health. Studies in animal models indicate that so-called epigenetic marks may be influenced by nutrition during development, [...]