Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with [...]

By |2021-07-20T08:24:10+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen [...]

By |2021-07-20T08:24:41+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Charting the dynamic methylome across the human lifespan

Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first [...]

By |2021-07-20T08:26:08+00:00July 5th, 2021|thesis epigenetics, thesis osteoarthritis|0 Comments

Thyroid hormone signalling in Osteoarthritis: early life events in late life disease

Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the In the field of Osteoarthritis (OA) research the step from genetics to biological functionality, also [...]

By |2021-07-20T08:26:29+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA

Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by pain, crepitus, and stiffness resulting in decreased mobility. Pathophysiology consists of cartilage degeneration and bone remodeling, however, knowledge of OA [...]

By |2021-07-20T08:27:54+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Genes and Mediators of Inflammation and Development in Osteoarthritis

Steffan Bos | 15-09-2010 | Genes and Mediators of Inflammation and Development in Osteoarthritis Osteoarthritis (OA) mainly affects the articular cartilage covering the bones. In this thesis we investigated the relation between levels of inflammatory mediators, genes involved in their regulation and the disease status of OA. We investigated the role of genetic variation [...]

By |2021-07-20T08:31:40+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease

Josine Min | 17-01-2007| Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease Osteoarthritis (OA) is a prevalent and complex disorder with a high hereditary probability. Previous genetic research into OA has yielded several common gene variants contributing to joint specific OA phenotypes. Only a few studies allowed an examination of multiple joint sites in the [...]

By |2021-07-20T08:32:58+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Familial osteorarthritis : risk factors and determinants of outcome

Naghmeh Riyazi | 22-11-2006 | Familial osteorarthritis : risk factors and determinants of outcome Osteoarthritis (OA) refers to a heterogeneous group of conditions. This thesis focuses on OA with a hereditary background; Familial OA at multiple joint sites and radiological hand OA at middle age. The main objective is to identify risk factors that [...]

By |2021-07-20T08:33:18+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Osteoarthritis and hemochromatosis, a genetic epidemiological study

B.Z. Alizadeh (Behrooz)| 23-03-2005 | Osteoarthritis and hemochromatosis, a genetic epidemiological study Osteoarthritis (OA) refers to a heterogeneous group of distinct diseases which express a common radiographic and clinical phenotype at diarthrodial joints.It is the leading cause of pain and disability in the elderly with a prevalence of 75 percent in the population [...]

By |2021-07-20T08:33:35+00:00July 5th, 2021|thesis osteoarthritis|0 Comments
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