Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis

Evelyn Houtman | 22-10-2022 | Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis This thesis aims to increase the understanding of human osteoarthritis pathophysiology by developing reliable biomimetic ex vivo human osteochondral explant models and focussing on the role of osteoarthritis-relevant triggers (mechanical stress) and interacting genetic factors [...]

Door |2023-11-22T08:03:43+00:00november 22nd, 2023|proefschrift artrose|0 Reacties

Osteoprotegerin: a double-edged sword in osteoarthritis development

Alejandro Rodríguez Ruiz | 22-09-2022 | Osteoprotegerin: a double-edged sword in osteoarthritis development To advance development of effective disease modifying OA treatments, a better understanding of its pathophysiological mechanisms is necessary. By studyinga family with early onset OA and high cartilage mineralization, a likely causal mutation in the TNF receptor superfamily member 11b (TNFRSF11B) [...]

Door |2023-11-22T07:51:16+00:00november 22nd, 2023|proefschrift artrose|0 Reacties

The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy

Margo Tuerlings | 27-09-2023 | The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy. Osteoarthritis (OA) is a prevalent age-related joint disease, determined by diverse changes in pathways maintaining articular cartilage and subchondral bone. This thesis aimed to identify and study gene networks driving interacting etiopathophysiological OA processes in cartilage and [...]

Door |2023-11-21T15:19:16+00:00november 21st, 2023|proefschrift artrose|0 Reacties

Dissecting cellular function of fibronectin in osteoarthritic cartilage

Marcella van Hoolwerff | 06-09-2022 | Dissecting cellular function of fibronectin in osteoarthritic cartilage The aim of this thesis was to combine transcriptomics, genetics and human disease modelling to obtain further insight into molecular processes underlying osteoarthritis. More specifically, we aimed to elucidate the role of long noncoding RNAs expression changes as aberrant epigenetic [...]

Door |2023-11-21T15:10:31+00:00november 21st, 2023|proefschrift artrose|0 Reacties

Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with [...]

Door |2021-07-20T08:22:53+00:00juli 5th, 2021|proefschrift artrose|0 Reacties

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen [...]

Door |2021-07-05T12:52:48+00:00juli 5th, 2021|proefschrift artrose|0 Reacties

Charting the dynamic methylome across the human lifespan

Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first [...]

Door |2021-07-05T12:40:06+00:00juli 5th, 2021|proefschrift artrose, proefschrift epigenetica|0 Reacties

Thyroid hormone signalling in Osteoarthritis: early life events in late life disease

Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the In the field of Osteoarthritis (OA) research the step from genetics to biological functionality, also [...]

Door |2021-07-05T12:32:41+00:00juli 5th, 2021|proefschrift artrose|0 Reacties

Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA

Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by pain, crepitus, and stiffness resulting in decreased mobility. Pathophysiology consists of cartilage degeneration and bone remodeling, however, knowledge of OA [...]

Door |2021-07-05T12:08:05+00:00juli 5th, 2021|proefschrift artrose|0 Reacties

Genes and Mediators of Inflammation and Development in Osteoarthritis

Steffan Bos | 15-09-2010 | Genes and Mediators of Inflammation and Development in Osteoarthritis Osteoarthritis (OA) mainly affects the articular cartilage covering the bones. In this thesis we investigated the relation between levels of inflammatory mediators, genes involved in their regulation and the disease status of OA. We investigated the role of genetic variation [...]

Door |2021-07-05T09:18:00+00:00juli 5th, 2021|proefschrift artrose|0 Reacties
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