Over Eka Suchiman

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So far Eka Suchiman has created 15 blog entries.

1H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints

1H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints | 2022 Jan;75:103764 | EBioMedicine | doi: 10.1016/j.ebiom.2021.103764 Bizzarri D, Reinders MJT, Beekman M, Slagboom PE, BBMRI-NL, van den Akker EB. Abstract Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. 'metabolomics', [...]

Door |2022-04-26T14:12:12+00:00april 26th, 2022|Papers ageing, Papers LCBC|0 Reacties

A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress

A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress | Osteoarthritis and Cartilage Open| 4(1) (2022) 100231 | doi: 10.1016/j.ocarto.2021.100231 R.G.M. Timmermans, N.G.C. Bloks, M. Tuerlings, M. van Hoolwerff, R.G.H.H. Nelissen, R.J.P. van der Wal, P.M. van der Kraan, A.B. Blom, M.H.J. van den [...]

Door |2022-04-19T14:45:37+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis

A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis | Hum Mol Genet | 2022 Jan 28:ddac017 | doi: 10.1093/hmg/ddac017. Katsoula G, Steinberg J, Tuerlings M, de Almeida RC, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini E. Abstract Osteoarthritis is a prevalent joint disease and a [...]

Door |2022-04-19T14:40:53+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease.

ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease| Osteoarthritis Cartilage | 2022 Feb 25:S1063-4584(22)00650-1 | doi: 10.1016/j.joca.2022.02.615 Monteagudo S, Cornelis FMF, Wang X, de Roover A, Peeters T, Quintiens J, Sermon A, de Almeida RC, Meulenbelt I, Lories RJ Summary Objectives To investigate how ANP32A, previously linked to the antioxidant [...]

Door |2022-04-19T14:35:52+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes

Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.  Rheumatology (Oxford)| 2022 Apr 5:keac202 | doi: 10.1093/rheumatology/keac202 Houtman E, Tuerlings M,  Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Abstract Objectives [...]

Door |2022-04-19T14:29:29+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization Rheumatology (Oxford) | 2022 Apr 12:keac232 | doi: 10.1093/rheumatology/keac232 Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, Freund C, Mummery C, Everts V, de Vries TJ, Ramos [...]

Door |2022-04-19T12:07:22+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

The role of TNFRSF11B in development of osteoarthritic cartilage.

The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) |  2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]

Door |2022-04-19T11:04:39+00:00april 19th, 2022|Nieuws, Papers artrose|0 Reacties

Fibronectin binding to collagen type II is crucial for articular chondrocytes to stay in a healthy steady state

Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this mutation in an in vitro OA disease model using human [...]

Door |2022-03-17T12:17:50+00:00november 9th, 2021|Nieuws, Papers artrose|0 Reacties

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers | Biomolecules| 13-09-2021 |  Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Nico Lakenberg, H. Eka D. Suchiman, Hailiang Mei, Margreet Kloppenburg, Rob G. H. H. Nelissen and Ingrid Meulenbelt To identify and validate circulating micro [...]

Door |2021-09-14T12:26:42+00:00september 14th, 2021|Papers artrose|0 Reacties
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