Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first [...]
Jenny van Dongen | 16-04-2015 | (Epi)genetics and twins The research described in this thesis was characterized by two major themes: the first was related to the question to which extent variation between individuals in inflammation biomarkers and metabolic syndrome traits are caused by the impact of genetic and environmental differences between people. The [...]
Rudolf Talens | 08-01-2015 |Studies into epigenetic variation and its contribution to cardiovascular disease Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully transmitted during mitosis and are generally stable in differentiated cells, but in contrast with the static genome, the epigenome retains [...]
Elmar Tobi | 29-10-2013 | Epigenetic differences after prenatal adversity: The Dutch Hunger Winter This thesis is a study on the link between early development and adult health. Studies in animal models indicate that so-called epigenetic marks may be influenced by nutrition during development, changing the expression of genes implicated in disease. Epigenetics may [...]
