Papers
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in [...]
Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis
Evelyn Houtman | 22-10-2022 | Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis This thesis aims to increase the understanding of human osteoarthritis pathophysiology by developing [...]
Osteoprotegerin: a double-edged sword in osteoarthritis development
Alejandro Rodríguez Ruiz | 22-09-2022 | Osteoprotegerin: a double-edged sword in osteoarthritis development To advance development of effective disease modifying OA treatments, a better understanding of its pathophysiological mechanisms is necessary. By [...]
The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy
Margo Tuerlings | 27-09-2023 | The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy. Osteoarthritis (OA) is a prevalent age-related joint disease, determined by diverse changes in pathways maintaining [...]
Dissecting cellular function of fibronectin in osteoarthritic cartilage
Marcella van Hoolwerff | 06-09-2022 | Dissecting cellular function of fibronectin in osteoarthritic cartilage The aim of this thesis was to combine transcriptomics, genetics and human disease modelling to obtain further insight [...]
A word of caution on the regression to the mean phenomenon in (biological) age prediction
A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue [...]