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So far admin has created 185 blog entries.

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  Eka d. Suchiman, Roman i. Koning, Carolina r. Jost, Aat a. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid Meulenbelt [...]

Door |2021-11-09T11:36:40+00:00november 9th, 2021|Nieuws, Papers artrose|0 Reacties

Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt Abstract Objective To gain insight in the expression profile [...]

Door |2021-11-09T10:42:48+00:00november 9th, 2021|Nieuws, Papers artrose|0 Reacties

Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

Door |2021-10-19T11:38:18+00:00oktober 19th, 2021|Nieuws, Papers ageing|0 Reacties

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis  AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 [...]

Door |2021-11-09T11:52:40+00:00oktober 14th, 2021|Papers artrose|0 Reacties

Improved selection of participants in genetic longevity studies: family scores revisited

Improved selection of participants in genetic longevity studies: family scores revisited | BMC Medicine | January 2021 Rodriguez-Girondo, M.; Berg, N. van den; Hof, M.H.; Beekman, M.; Slagboom, E. Background: Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited [...]

Door |2021-10-11T13:53:47+00:00oktober 11th, 2021|Papers ageing|0 Reacties

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

Door |2021-10-11T13:45:03+00:00oktober 11th, 2021|Nieuws, Papers ageing|0 Reacties

Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study

Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study | Diabetes| August 2021 | Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi [...]

Door |2021-10-11T13:56:47+00:00oktober 11th, 2021|Papers ageing|0 Reacties

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients | EMBO Mol Med | April 2021 Mirko Signorelli, Mitra Ebrahimpoor, Olga Veth, Kristina Hettne, Nisha Verwey, Raquel García-Rodríguez,  Christa L Tanganyika-deWinter, Luz B Lopez Hernandez, Rosa Escobar Cedillo, Benjamín Gómez Díaz, Olafur T Magnusson, Hailiang Mei, Roula Tsonaka, Annemieke Aartsma-Rus, Pietro Spitali Abstract DMD is a rare disorder characterized by progressive muscle degeneration and [...]

Door |2021-10-11T12:47:20+00:00oktober 11th, 2021|paper bioinformatica, Papers ageing|0 Reacties

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells | Genome Med | 2021 Mar 24 Shadi Darvish Shafighi, Szymon M Kiełbasa, Julieta Sepúlveda-Yáñez, Ramin Monajemi,  Davy Cats, Hailiang Mei, Roberta Menafra, Susan Kloet, Hendrik Veelken,  Cornelis A M van Bergen, Ewa Szczurek  Abstract Background: Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. [...]

Door |2021-10-11T12:37:10+00:00oktober 11th, 2021|paper bioinformatica|0 Reacties

Cingulate networks associated with gray matter loss in Parkinson’s disease show high expression of cholinergic genes in the healthy brain

Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain | Eur J Neurosci | June 2021 Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D J van de Berg, Jacobus J van Hilten,  Marcel J T Reinders, Ahmed Mahfouz  Abstract Structural covariance networks are able to identify [...]

Door |2021-10-11T12:30:09+00:00oktober 11th, 2021|paper bioinformatica|0 Reacties
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