A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue before drawing conclusions. Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Hein Putter and Mar Rodríguez-Girondo posted a PubPeer comment (a postpublication [...]
Doe mee aan de gratis mini-cursus ‘Vitaal en gezond ouder worden’ Wat is veroudering eigenlijk? Komt er straks een anti-verouderingspil? Hoeveel moet ik bewegen en wat kan ik het beste eten? In de gratis 8-delige mini-cursus ‘Vitaal en gezond ouder worden’ praten Nederlandse topwetenschappers je bij over de laatste inzichten uit wetenschappelijk onderzoek naar veroudering. De [...]
Onderzoekers kunnen aan de hand van de afstelling van het DNA nauwkeurig vaststellen hoe oud iemand is. Daarvoor gebruiken ze een zogeheten epigenetische klok. Masterstudent Thomas Jonkman heeft nu, negen jaar na de ontdekking, ontrafeld hoe deze klok precies werkt: het blijkt de veroudering van ons immuunsysteem bij te houden. Met deze kennis kan [...]
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt Abstract Objective To gain insight in the expression profile [...]
Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 [...]
Improved selection of participants in genetic longevity studies: family scores revisited | BMC Medicine | January 2021 Rodriguez-Girondo, M.; Berg, N. van den; Hof, M.H.; Beekman, M.; Slagboom, E. Background: Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited [...]
Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]
Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study | Diabetes| August 2021 | Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi [...]
