Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma , K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, and I M Meulenbelt Abstract Introduction Pathologically high growth hormone [...]
Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | eclinicalmedicine Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias [...]
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | 20-02-2021 | Rheumatology and Therapy Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H. D. Suchiman, Enrike van der Linden-van der Zwaag, Rob G. H. H. Nelissen, Yolande F. M. Ramos & Ingrid Meulenbelt Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) [...]
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida & Ingrid Meulenbelt Background Failing of intrinsic [...]
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink ... Show more Abstract Objective To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or [...]
Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers | 12-02-2020 | A Journal of Demography Niels van den Berg, Ingrid K. van Dijk, Rick J. Mourits, P. Eline Slagboom, Angelique A.P.O. Janssens & Kees Mandemakers Identifying genes that code for proteins associated to longevity is [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | 12-11-2020 | Leukemia Erik B. van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H. Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E. Jakobs, Daphne de Jong, P. Eline Slagboom, Frank J. T. Staal, Marcel J. T. Reinders & Henne Holstege Age-related Clonal hematopoiesis (ARCH) is an inevitable consequence of ageing, which arises when [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer147KonstantinosHatzikotoulas247LorraineSoutham247LiljaStefánsdóttir3YanfeiZhang4RodrigoCoutinho de Almeida5Tian T.Wu6JieZheng7AprilHartley78MarisTeder-Laving9Anne HeidiSkogholt10ChikashiTerao11EleniZengini12GeorgeAlexiadis13AndreiBarysenka2GydaBjornsdottir3Maiken E.Gabrielsen10ArthurGilly2…EleftheriaZeggini24648 Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of [...]
Prof. Eline Slagboom heeft de Karl Ludwig Schoberprijs voor vooraanstaand verouderingsonderzoek gekregen Op vrijdag 10 september 2021 heeft Prof. Eline Slagboom de Karl Ludwig Schobert prijs in ontvangst genomen in Halle, Duitsland. Sinds 2003 wordt de Karl Ludwig Schoberprijs om de twee jaar uitgereikt aan gerenommeerde geriatrische onderzoekers. Karl-Ludwig Schober (13 juli 1912 - † 11 oktober 1999) was een [...]
Nature Genetics | 6 september 2021 Het effect van genetica op epigenetica gepubliceerd in Nature Genetics Nature Genetics publiceerde deze week het resultaat van een grootschalige internationale studie naar de invloed van genetica op DNA methylatie, een essentiële epigenetische factor. Het was het resultaat van een samenwerking tussen meer dan 150 onderzoekers van 50 [...]
