Daniele Bizzarri  | 11-09-2024 | Metabolomics- and methylomics-based predictors for estimating health and biological aging Over the past decade, the abundance of high-throughput omics approaches coupled with the use of machine learning techniques, has made it possible to investigate the full molecular complexity of [...]

Niels van den Berg | 22-01-2020 | Family matters: a genealogical inquiry into the familial component of longevity Identifying genes that code for proteins associated to longevity is an important aspect of aging research. These longevity genes likely represent key mechanisms of a life-long decreased [...]

Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life [...]

Jesse Krijthe | 07-01-2018 | Robust semi-supervised learning: projections, limits & constraints In many domains of science and society, the amount of data being gathered is increasing rapidly. To estimate input-output relationships that are often of interest, supervised learning techniques rely on a specific [...]

Jonathan Vis | 21-12-2016 | Algorithms for the Description of Molecular Sequences Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society (HGVS) describes the observed variant sequence relative to a given reference [...]

Marjon Stijntjes | 12-10-2016 |A Study into Genes Encoding Longevity in Humans Human ageing is characterized by a gradual decline in cognitive and physical performance strongly determining someone’s functional abilities and quality of life. In this thesis, insights into these age-related changes and most [...]