Dissertations Osteoarthritis2021-07-19T13:24:45+00:00

Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe [...]

July 5th, 2021|Categories: thesis osteoarthritis|

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose [...]

July 5th, 2021|Categories: thesis osteoarthritis|

Charting the dynamic methylome across the human lifespan

Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation [...]

July 5th, 2021|Categories: thesis epigenetics, thesis osteoarthritis|

Thyroid hormone signalling in Osteoarthritis: early life events in late life disease

Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the In the field of Osteoarthritis [...]

July 5th, 2021|Categories: thesis osteoarthritis|

Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA

Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by pain, crepitus, and stiffness resulting in decreased mobility. Pathophysiology consists [...]

July 5th, 2021|Categories: thesis osteoarthritis|

Genes and Mediators of Inflammation and Development in Osteoarthritis

Steffan Bos | 15-09-2010 | Genes and Mediators of Inflammation and Development in Osteoarthritis Osteoarthritis (OA) mainly affects the articular cartilage covering the bones. In this thesis we investigated the relation between levels of inflammatory mediators, genes involved in their regulation and the disease [...]

July 5th, 2021|Categories: thesis osteoarthritis|
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