Molecular Epidemiology: Developments in ageing research

Exciting approaches to ageing research. Why do some people survive into their nineties and can still ride their bikes, while others age faster in poor health? The Molecular Epidemiology department of the LUMC conducts research into the origin of these differences and how these differences can be reduced.

What affects the ageing rate?

Which mechanisms play a role in this? To investigate this, the researchers are looking at factors that cause people to age healthily. Research is being conducted in long-lived families for this. In these families, the majority manage to reach the age of ninety. What is their secret? Which genes are beneficial? What makes their bodies different from other people? Within this context, we focus on a healthy metabolism, disease and osteoarthritis.

Furthermore, we focus on patients and population-based cohorts such as families who develop osteoarthritis in middle age (GARP), long-lived families (Leiden LangLeven Study), population-based elderly (Leiden 85+ Study and populations exposed to adverse conditions early in the life (the Dutch Hunger Winter study)

Dutch biobanks

In collaboration with various Dutch Biobanks, we integrate studies by following newborn babies to middle-aged and long-lived patients. We use serum parameters, genetic and (epi)genomic images, metabolic data and lifestyle questionnaires. We use modern techniques for this. We study extensive biological information from donors that is stored in biobank databases (primary skin cells, peripheral blood cells, mesenchymal stem cells). Through national and international partnerships (BBMRI), we are deeply involved in organizing the infrastructure and the statistical and bioinformatics pipelines needed to analyze the data obtained by the latest omicstechnologies.

Collaboration worldwide

Our research is closely linked to aging research within global and European research groups, in which our scientists participate or have a leading role. Under the leadership of Prof.dr. Eline Slagboom focuses the expertise of Molecular Epidemiology in different research areas: osteoarthritis, metabolic or cardiovascular disease, aging and longevity and the field of epigenetics and bioinformatics.

International

AGEING

 

The aim of the research at the department of molecular epidemiology is to identify mechanisms that contribute to healthy aging and longevity.

Partnerships

OSTEOARTHRITIS

 

Osteoarthritis is the most common chronic disease in our country. As many as 1.2 million people have osteoarthritis and struggle daily with the pain and movement limitations that osteoarthritis entails.

Excellence

BIO INFORMATICS

 

Bioinformatics is a field that focuses on devising and developing new methods at the interface of informatics and statistics that help us increase our understanding of biological processes.

Excellence

EPIGENETICS

 

A brain cell does very different things than a liver cell. It also looks completely different. Yet their DNA is identical within one person.

ALL EMPLOYEES

Prof.dr. Eline Slagboom

Section head of the department of Molecular Epidemiology

Inge ten Hoorn

Management assistent

Prof. dr. Ingrid Meulenbelt

Professor Molecular Biology of Osteoarthritis

prof.dr. Marcel Reinders

Head Leiden Computational Biology Center – LCBC

prof.dr. Bas Heijmans

Professor of Population Epigenomics

dr. Yolande Ramos

Senior researcher

dr. Marian Beekman

Senior researcher

dr. Leen ‘t Hart

Senior Researcher

dr. ir. Erik van den Akker

Senior researcher

dr. Leon Mei

Manager Sequencing Analysis Support Core

dr. Niels van den Berg

Researcher

ing. Nico Lakenberg

Research analist

drs. Eka Suchiman

Research analist

Laura Franken

Research analist

drs. Joyce Vriezen

Programma manager

dr. Ghazaleh Hajmousa

Senior researcher

dr. Rodrigo Almeida de Coutinho

Post doctoraal onderzoeker

dr. Dina Vojinovic-Dees

Senior researcher

Stelios Paraschiakos Msc

Phd-student

Margot Tuerlings Msc

Phd-student

Ruben Vorderman

Application developer

Alejandro Rodriguez Ruiz Msc

Phd-student

Ritchie Timmermans Msc

Phd-student

Pia Todtenhaupt Msc

Phd-student

Nathalie Reilly Msc

Phd-student

Lucy Sinke Msc

Phd-student

Ioannis Moustakas

Research analist

Marcella van Hoolwerff Msc

Phd-student

Evelyn Houtman Msc

Phd-student

Jasper Boom

Research analist

dr. Nicoline Korthagen

Senior researcher

Koen Dekkers Msc

Phd-student

Fatih Boogaards Msc

Phd-student

Daniele Bizzari Msc

Phd-student

ing. Davy Cats

Bio informaticus

Niek Bloks Msc

Phd-student

Cedrick Agaser

Research analist

Tom Kuipers

Research analist

Onur Karakaslar Msc

Phd-student

Jeppe Severens Msc

Phd-student

Ilja Boone Msc

Phd-student

Yunfeng Liu Msc

Phd-student

Kerstin Schorr Msc

Phd-student

Mathew Nickel Msc

Phd-student