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Nature Reviews Cardiology publication about T cells in atherosclerosis

Nature Reviews Cardiology published an article about the effects of fatty acids on T cells and the implications for atherosclerosis led by LUMC-researchers Wouter Jukema (Cardiology) and Bas Heijmans (Biomedical Data Sciences)  It’s high time for more attention to be paid to T cells in cardiovascular research, because atherosclerotic plaques are full of [...]

July 20th, 2021|0 Comments

Family matters: a genealogical inquiry into the familial component of longevity

Niels van den Berg | 22-01-2020 | Family matters: a genealogical inquiry into the familial component of longevity Identifying genes that code for proteins associated to longevity is an important aspect of aging research. These longevity genes likely represent key mechanisms of a life-long decreased mortality and a decreased probability of age-related disease causing persons [...]

July 5th, 2021|0 Comments

 Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries

Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life was unexceptional. He was a farmer’s son and he worked [...]

July 5th, 2021|0 Comments

From correlation to causation: Data-driven exploration of transcriptional regulation using population genomics

René Luijk | 16-10-2019 |A Study into Genes Encoding Longevity in Humans In this thesis, we aimed to better understand how genetic variation affect the processes underlying health and disease, as trait-associated genetic variants are often located in non-coding regions. This hampers their interpretability, and has prompted the exploration of their effects on transcriptional [...]

July 5th, 2021|0 Comments

Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with [...]

July 5th, 2021|0 Comments

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen [...]

July 5th, 2021|0 Comments
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