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The role of TNFRSF11B in development of osteoarthritic cartilage.

The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) |  2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]

April 19th, 2022|0 Comments

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]

November 9th, 2021|0 Comments

Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state

Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this mutation in an in vitro OA disease model using human [...]

November 9th, 2021|0 Comments

Functional Changes of T-Cell Subsets with Age and CMV Infection

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]

October 19th, 2021|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated [...]

October 11th, 2021|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | October 2021 |American Diabetes Association Sofia Thomaidou, Roderick C. Slieker, Arno R. van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M. ‘t Hart, Bobby Koeleman, Françoise Carlotti, Rob C. Hoeben, Bart O. Roep, Hailiang Mei and Arnaud [...]

October 9th, 2021|0 Comments
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