LATEST NEWS
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function as biomarkers for patient-tailored targeting of senescence in OA. Accumulation [...]
The role of TNFRSF11B in development of osteoarthritic cartilage.
The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) | 2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]
Leiden master’s student cracks epigenetic clock that predicts age – newsitem LUMC 14-01-2022
Researchers can accurately determine how old a person is based on the calibration of the DNA. To do this, they use a so-called epigenetic clock. Master's student Thomas Jonkman has now, nine years after the discovery, unravelled how this clock exactly works: it turns out to keep track of the ageing of our immune [...]
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman i. Koning, Carolina r. Jost, Aat a. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]
Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state
Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this mutation in an in vitro OA disease model using human [...]
Functional Changes of T-Cell Subsets with Age and CMV Infection
Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is [...]