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ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline
Swier Garst,[...], P Eline Slagboom, Joyce van Meurs | 18-05-2026 | Because individuals age at different rates, robust aging biomarkers are needed beyond chronological age. However, the methodological choices that shape such biomarkers have not been compared in a unified framework. This study addresses that gap by evaluating model choice, training targets, and protein [...]
Nuclear Factor I genes drive chondrogenic cell-fate commitment
Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from 7 time points during a 49-day chondrogenic hiPSC differentiation protocol using single-nucleus multimodal [...]