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MOLECULAR EPIDEMIOLOGY

A long and healthy life is not for everyone. Why is one person worn out at the age of sixty while another can still cycle at the age of ninety? The Molecular Epidemiology department of the LUMC conducts research into the origin of these differences and how these differences can be reduced.

What affects the aging rate? Which mechanisms play a role in this? To investigate this, the researchers are looking at factors that cause people to age healthily. To this end, research is being conducted in long-lived families. In these families the majority manage to reach the age of ninety. What is their secret? Which genes are beneficial? What makes their bodies different from other people? Within this context, we focus on a healthy metabolism, disease and osteoarthritis.

OUR RESEARCH

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OUR RESEARCH

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OUR TEAM

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MISSIE

Epidemiology combines expertise in molecular epidemiology and computer science. This expertise is used for research, education and advice in order to contribute to the improvement of healthcare.

The mission of the research conducted within Molecular Epidemiology (MolEpi) is to monitor and understand factors that influence the risk of age-related disease(s) – aging – or the inverse factors involved in healthy aging. To this end, we generate and analyze state-of-the-art molecular data in human populations, families and groups of patients. In addition, in this context we focus on metabolic health and the relationship to cardiovascular disease. The research is anchored in themes and is carried out in three related research areas and the associated study populations: Aging osteoarthritis and epigenetic epidemiological research. The populations involved in these studies are also linked in biobanks within the BBMRI community.

For information about advice and cooperation with the Molecular Epidemiology section, please refer to this page.

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Partnerships

OSTEOARTHRITIS

Excellence

BIO INFORMATICS

Excellence

EPIGENETICS

International

AGEING

LATEST NEWS

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma , K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R [...]

September 15th, 2021|Papers artrose|

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | 20-02-2021 | Rheumatology and Therapy Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H. D. Suchiman, Enrike van der Linden-van der Zwaag, Rob G. H. H. Nelissen, Yolande F. M. Ramos & Ingrid Meulenbelt Introduction [...]

September 15th, 2021|Papers artrose|
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