Theses ageing
Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial
Bogaards FA, Groenendijk I, [...], Slagboom PE | 17-04-2026 | Nutritional weight-loss interventions are known to reduce bone mineral density (BMD), which can be prevented by adding (resistance) exercise training. However, this combined effect is not well studied in non-obese adults. In addition, the [...]
Modeling the genetic and mechanical interplay in osteoarthritis: from in vitro systems to mechanistic insights
Niek Bloks| 22-10-2025 | Modeling the genetic and mechanical interplay in osteoarthritis: from in vitro systems to mechanistic insights Osteoarthritis (OA) is a multi-factorial degenerative disease of joint tissues in which the etio-pathophysiology revolves around the interplay between genetic and environmental risk factors. In [...]
Exploring senescent chondrocytes during aging: sleeper AGEnts of osteoarthritis
Ilja Boone | 17-10-2025 | Exploring senescent chondrocytes during aging: sleeper AGEnts of osteoarthritis Osteoarthritis is a painful, age-related joint disease in which cellular senescence plays a central role. Senescent cells are retained from the active cell cycle and secrete harmful factors that contribute [...]
Invitation: MOLEPI symposium 2025
INVITATION: MOLEPI Symposium In celebration of our 25th ANNIVERSARY, we WILL BE hosting a special symposium to reflect on our journey and explore the future of molecular epidemiology 📅 THURSDAY, OCTOBER 30, 2025 ⌚ 13:30 – 18:00 📍 LUMC, BUILDING 1, LECTURE [...]
Invitation: MOLEPI reunion 2025
Invitation: MOLEPI reunion 2025 We will be hosting a reunion for all our former and present colleagues over the past 25 years 📅 SATURDAY NOVEMBER 1, 2025 ⌚ 14:00 – 18:00 📍 LUMC, BUILDING 2, The Restaurant Let’s celebrate! Sign up here: [...]
Effects of lipids on DNA methylation and gene expression of immune cells implicated in atherosclerosis
Koen Dekkers | 16-01-2025 | Effects of lipids on DNA methylation and gene expression of immune cells implicated in atherosclerosis Cardiovascular diseases, the leading cause of death worldwide, are often the result of atherosclerosis, a chronic inflammatory disease where lipids and immune cells accumulate [...]