Theses ageing
Unravelling the developmental origins of disease: the power of mesenchymal stromal cells and monochorionic twins
Pia Todtenhaupt | 18-12-2024 | Unravelling the developmental origins of disease: the power of mesenchymal stromal cells and monochorionic twins This thesis explores the mechanisms linking adverse intrauterine environments to long-term health risks. Therefore, the Twinlife study was established. This study includes monochorionic (MC) twins [...]
The effects of triglycerides and fatty acids on T cells: role in atherosclerosis
Nathalie Reilly | 30-10-2024 | The effects of triglycerides and fatty acids on T cells: role in atherosclerosis Atherosclerosis, a leading cause of cardiovascular disease, is characterized by lipid accumulation in blood vessel walls. This chronic inflammation leads to plaque formation, increasing the risk [...]
Metabolomics- and methylomics-based predictors for estimating health and biological aging
Daniele Bizzarri | 11-09-2024 | Metabolomics- and methylomics-based predictors for estimating health and biological aging Over the past decade, the abundance of high-throughput omics approaches coupled with the use of machine learning techniques, has made it possible to investigate the full molecular complexity of [...]
Depressive symptoms and plasma markers of Alzheimer’s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies
Depressive symptoms and plasma markers of Alzheimer's disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and [...]
Healthful plant-based diet associates with greater well-being in older adults
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact [...]
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function [...]