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Cingulate networks associated with gray matter loss in Parkinson’s disease show high expression of cholinergic genes in the healthy brain

Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain | Eur J Neurosci | June 2021 Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D J van de Berg, Jacobus J van Hilten,  Marcel J T Reinders, Ahmed Mahfouz  Abstract Structural covariance networks are able to identify [...]

By |2021-10-11T13:57:35+00:00October 11th, 2021|paper bioinformatica|0 Comments

CBA: Cluster-Guided Batch Alignment for Single Cell RNA-seq

CBA: Cluster-Guided Batch Alignment for Single Cell RNA-seq | April 2021 | Frontiers in Genetics |DOI:10.3389/fgene.2021.644211 Wenbo Yu, Ahmed Mahfouz, Marcel J.T. Reinders Abstract and Figures The power of single-cell RNA sequencing (scRNA-seq) in detecting cell heterogeneity or developmental process is becoming more and more evident every day. The granularity of this knowledge is further propelled [...]

By |2021-10-11T13:57:48+00:00October 11th, 2021|paper bioinformatica|0 Comments

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

Maxime M. Bos, Neil J. Goulding, Matthew A. Lee, Amy Hofman, Mariska Bot, René Pool, Lisanne S. Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R. Biermasz, Dorret I. Boomsma, Irene de Boer, Constantinos Christodoulides, Abbas Dehghan, Ko Willems van Dijk, Ian Ford, Mohsen Ghanbari, [...]

By |2021-10-11T13:58:02+00:00October 11th, 2021|Papers ageing|0 Comments

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | October 2021 |American Diabetes Association Sofia Thomaidou, Roderick C. Slieker, Arno R. van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M. ‘t Hart, Bobby Koeleman, Françoise Carlotti, Rob C. Hoeben, Bart O. Roep, Hailiang Mei and Arnaud [...]

By |2021-11-09T13:18:49+00:00October 9th, 2021|News, papers SASC|0 Comments

Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing

Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing | January 2021 | Leukemia. 2021 Jan;35(1):47-61. doi: 10.1038/s41375-020-0762-8. Epub 2020 Mar 3. PMID: 32127641. Arindrarto W, Borràs DM, de Groen RAL, van den Berg RR, Locher IJ, van Diessen SAME, van der Holst R, van der Meijden ED, Honders MW, de Leeuw [...]

By |2021-09-27T09:13:32+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments

The Transcriptome in Transition: Global Gene Expression Profiles of Young Adult Fruit Flies Depend More Strongly on Developmental Than Adult Diet

The Transcriptome in Transition: Global Gene Expression Profiles of Young Adult Fruit Flies Depend More Strongly on Developmental Than Adult Diet | March 2021 | Front. Ecol. Evol. May CM, van den Akker EB, Zwaan BJ Abstract Developmental diet is known to exert long-term effects on adult phenotypes in many animal species as well [...]

By |2021-09-27T09:13:46+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments

The trans-ancestral genomic architecture of glycemic traits

The trans-ancestral genomic architecture of glycemic traits | Nat Genet | June 2021 Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, …, Erik van den Akker, …, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A. Abstract Glycemic traits are used to diagnose and monitor type [...]

By |2021-09-27T09:14:00+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments

Discovering fiber type architecture over the entire muscle using data-driven analysis

Discovering fiber type architecture over the entire muscle using data-driven analysis | June 2021 | Cytometry A Bindellini D, Voortman LM, Olie Cyriel S, van Putten M, van den Akker EB, Raz V. Abstract Skeletal muscle function is inferred from the spatial arrangement of muscle fiber architecture, which corresponds to myofiber molecular and metabolic [...]

By |2021-10-11T13:58:15+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments

Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations

Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations | Genes Immun | July 2021 Khatri I, Berkowska MA, van den Akker EB, Teodosio C, Reinders MJT, van Dongen JJM. Abstract Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity [...]

By |2021-09-27T09:14:28+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020 van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Age-related Clonal hematopoiesis (ARCH) is an inevitable [...]

By |2021-09-27T09:14:42+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments
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