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 Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries

Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life was unexceptional. He was a farmer’s son and he worked [...]

By |2021-07-20T08:43:48+00:00July 5th, 2021|thesis ageing|0 Comments

From correlation to causation: Data-driven exploration of transcriptional regulation using population genomics

René Luijk | 16-10-2019 |A Study into Genes Encoding Longevity in Humans In this thesis, we aimed to better understand how genetic variation affect the processes underlying health and disease, as trait-associated genetic variants are often located in non-coding regions. This hampers their interpretability, and has prompted the exploration of their effects on transcriptional [...]

By |2021-07-20T08:23:32+00:00July 5th, 2021|thesis ageing|0 Comments

Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling.

Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with [...]

By |2021-07-20T08:24:10+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

On the relation between genetic variation and osteoarthritis

Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen [...]

By |2021-07-20T08:24:41+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Robust semi-supervised learning: projections, limits & constraints

Jesse Krijthe | 07-01-2018 | Robust semi-supervised learning: projections, limits & constraints In many domains of science and society, the amount of data being gathered is increasing rapidly. To estimate input-output relationships that are often of interest, supervised learning techniques rely on a specific type of data: labeled examples for which we know both [...]

By |2021-07-20T08:25:02+00:00July 5th, 2021|thesis ageing|0 Comments

Charting the dynamic methylome across the human lifespan

Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first [...]

By |2021-07-20T08:26:08+00:00July 5th, 2021|thesis epigenetics, thesis osteoarthritis|0 Comments

Thyroid hormone signalling in Osteoarthritis: early life events in late life disease

Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the In the field of Osteoarthritis (OA) research the step from genetics to biological functionality, also [...]

By |2021-07-20T08:26:29+00:00July 5th, 2021|thesis osteoarthritis|0 Comments

Algorithms for the Description of Molecular Sequences

Jonathan Vis | 21-12-2016 | Algorithms for the Description of Molecular Sequences Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society (HGVS) describes the observed variant sequence relative to a given reference sequence. We propose an efficient algorithm for the extraction of HGVS descriptions [...]

By |2021-07-20T08:26:54+00:00July 5th, 2021|thesis ageing|0 Comments

Interactions of cognitive and physical ageing

Marjon Stijntjes | 12-10-2016 |A Study into Genes Encoding Longevity in Humans Human ageing is characterized by a gradual decline in cognitive and physical performance strongly determining someone’s functional abilities and quality of life. In this thesis, insights into these age-related changes and most importantly their interactions are given, which might be suggestive for [...]

By |2021-07-20T08:27:12+00:00July 5th, 2021|thesis ageing|0 Comments

Genetics and epigenetics of repeat derepression in human disease

Peter Thijssen| 01-09-2016 | Genetics and epigenetics of repeat derepression in human disease A large part of the human genome consists of repetitive DNA. In this thesis two human diseases have been studied in which deregulation of repetitive DNA is a central feature: facioscapulohumeral muscular dystrophy (FSHD) and immunodeficiency, centromere instability and facial anomalies [...]

By |2021-07-20T08:41:45+00:00July 5th, 2021|thesis epigenetics|0 Comments
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