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Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations

Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations | Genes Immun | July 2021 Khatri I, Berkowska MA, van den Akker EB, Teodosio C, Reinders MJT, van Dongen JJM. Abstract Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity [...]

By |2021-09-27T09:14:28+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments
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Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020 van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Age-related Clonal hematopoiesis (ARCH) is an inevitable [...]

By |2021-09-27T09:14:42+00:00September 27th, 2021|paper bioinformatica, Papers ageing|0 Comments
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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation | September 2021 |Nature Genetics Josine L Min, Gibran Hemani, Eilis Hannon, Koen F Dekkers, Juan Castillo-Fernandez, René Luijk, ................................., Tom R Gaunt, Jordana T Bell, Bastiaan T Heijmans, Jonathan Mill, Caroline L Relton  Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and [...]

By |2021-09-21T12:27:34+00:00September 21st, 2021|Papers epigenetica|0 Comments
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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations |September 2021 |Cell Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida,........., Rob R G H H Nelissen, Margo Tuerlings, arcOGEN Consortium,.................., Ingrid Meulenbelt  , Ming Ta Michael Lee, Joyce B J van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini Abstract Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide [...]

By |2021-09-21T12:27:49+00:00September 21st, 2021|News, Papers artrose|0 Comments
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Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis

Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis | August 2021 | JAMA Internal Medicin Nicolien A van Vliet, Diana van Heemst, Osvaldo P Almeida, Bjørn O Åsvold, Carole E Aubert, Jong Bin Bae, Linda E Barnes, Douglas C Bauer, Gerard J Blauw, Carol Brayne, Anne R Cappola, Graziano Ceresini, Hannie C Comijs , Jean-Francois Dartigues  ,Jean-Marie Degryse , Robin P F Dullaart, Marlise E A van Eersel  [...]

By |2021-09-22T10:52:14+00:00September 21st, 2021|Papers ageing|0 Comments
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Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis

Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis | August 2021 | The Journal of Pathology Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter Ten Dijke  Abstract Chondrocytes in mice developing osteoarthritis (OA) exhibit an aberrant response to the secreted cytokine transforming [...]

By |2021-09-21T12:38:22+00:00September 21st, 2021|Papers artrose|0 Comments
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Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian  | July 2021 | Leukemia Erik B van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E Jakobs, Daphne de Jong, P Eline Slagboom, Frank J T Staal, Marcel J T Reinders, Henne Holstege  Link to whole paper

By |2021-09-22T07:55:54+00:00September 21st, 2021|Papers ageing|0 Comments
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Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study

Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study | July 2021 | Frontiers in Microbiology Patrizia D'Aquila, Robertina Giacconi, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune , Efstathios S Gonos, Claudio Franceschi, Miriam Capri, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Christiane Schön, Jürgen Bernhardt, Nicolle Breusing, Giuseppe Passarino, Mauro Provinciali , Dina Bellizzi [...]

By |2021-09-22T07:56:54+00:00September 21st, 2021|Papers ageing|0 Comments
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Effects of fatty acids on T cell function: role in atherosclerosis Nathalie A Reilly 1 2,

Effects of fatty acids on T cell function: role in atherosclerosis | July 2021 | Nat Rev Cardiol Nathalie A Reilly, Esther Lutgens, Johan Kuiper, Bastiaan T Heijmans, J Wouter Jukema Abstract T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. [...]

By |2021-09-21T12:29:03+00:00September 21st, 2021|Papers epigenetica|0 Comments
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Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study  | June 2021 | Geroscience Maria Giulia Bacalini, Anna Reale, Marco Malavolta, Fabio Ciccarone, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Miriam Capri, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Nicolle Breusing, Valentina Aversano, Stefano Tagliatesta, Claudio Franceschi, Maria A Blasco, Alexander [...]

By |2021-09-21T12:29:16+00:00September 21st, 2021|Papers ageing|0 Comments
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Moleculaire Epidemiologie  | copyright 2021

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