Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study | June 2021 | Metabolomics Wenyi Wang, Ko Willems van Dijk, Carolien A Wijsman, Maarten P Rozing, Simon P Mooijaart, Marian Beekman, P Eline Slagboom, J Wouter Jukema, Raymond Noordam, Diana van Heemst Abstract Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin [...]

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | May 2021 | Elife Heli Julkunen, Anna Cichońska, P Eline Slagboom  , Peter Würtz, Nightingale Health UK Biobank Initiative Abstract Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to [...]

Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study  | May 2021 | J Gerontol A Biol Sci Med Sci Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Andrea Basso, Alexander Bürkle, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix [...]

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains | March 2021 | Scientific Reports L Kananen, L Enroth, J Raitanen, J Jylhävä, A Bürkle, M Moreno-Villanueva, J Bernhardt, O Toussaint, B Grubeck-Loebenstein, M Malavolta, A Basso, F Piacenza, S Collino, E S Gonos, E Sikora, D Gradinaru  E H J M Jansen, M E T Dollé, M Salmon, W Stuetz D , Weber, T [...]

Correction for both common and rare cell types in blood is important to identify genes that correlate with age | March 2021 | BMC Genomics Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, BIOS Consortium, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra & Lude Franke Abstract BACKGROUND: Aging is a multifactorial process that [...]

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults | February 2021 | The Journal of Infectious Diseases Sijia Chen, Graham Pawelec, Stella Trompet, David Goldeck, Laust H. Mortensen, P. Eline Slagboom, Kaare Christensen, Jacobijn Gussekloo, Patricia Kearney, Brendan M. Buckley, Ian Ford, J. Wouter Jukema, Rudi G.J. Westendorp, Andrea B. [...]