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Omixer: multivariate and reproducible sample randomization to proactively counter batch effects in omics studies

Omixer: multivariate and reproducible sample randomization to proactively counter batch effects in omics studies | March 2021 | Bioinformatics Lucy Sinke, Davy Cats, Bastiaan T Heijmans Abstract Motivation: Batch effects heavily impact results in omics studies, causing bias and false positive results, but software to control them preemptively is lacking. Sample randomization prior to measurement is vital [...]

By admin|2021-09-21T12:31:15+00:00September 20th, 2021|paper bioinformatica, Papers epigenetica|0 Comments

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults | February 2021 | The Journal of Infectious Diseases Sijia Chen, Graham Pawelec, Stella Trompet, David Goldeck, Laust H. Mortensen, P. Eline Slagboom, Kaare Christensen, Jacobijn Gussekloo, Patricia Kearney, Brendan M. Buckley, Ian Ford, J. Wouter Jukema, Rudi G.J. Westendorp, Andrea B. [...]

By admin|2021-09-21T12:31:28+00:00September 20th, 2021|Papers ageing|0 Comments

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies |February 2021|J Dev Orig Health Dis Emilie M Herzog 1, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Janine F Felix, Andrew P Stubbs, Peter J van der Spek, Joyce B J van Meurs, Bastiaan T Heijmans, Régine P M Steegers-Theunissen Abstract Epigenetic programming is essential [...]

By admin|2021-09-21T12:31:41+00:00September 20th, 2021|Papers epigenetica|0 Comments

Reply to ‘Early-life exposure to the Chinese Famine and subsequent T2DM’

Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM' | February 2021 | Nature reviews endocrinology Chihua Li, Elmar W Tobi, Bastiaan T Heijmans, L H Lumey

By admin|2021-09-21T12:31:54+00:00September 20th, 2021|Papers epigenetica|0 Comments

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | E Clinical Medicine Sophie G.Groene, Jip A.Spekman, Arjan B.te Pas, Bastiaan T.Heijmans, Monique C.Haak, Jeanine M.M.van Klink, Arno A.W.Roest, Enrico Lopriore Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung [...]

By admin|2021-09-21T12:32:05+00:00September 20th, 2021|Papers epigenetica|0 Comments

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma, K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, I M Meulenbelt Abstract Introduction: Pathologically high growth hormone [...]

By admin|2021-09-21T12:33:58+00:00September 20th, 2021|Papers ageing, Papers artrose|0 Comments

DNA methylation differences at birth after conception through ART

DNA methylation differences at birth after conception through ART | January 2021 | Human Reproduction Elmar W Tobi, Catarina Almqvist, Anna Hedman, Ellika Andolf , Jan Holte, Jan I Olofsson, Håkan Wramsby, Margaretha Wramsby, Göran Pershagen, Bastiaan T Heijmans, Anastasia N Iliadou Abstract Study question: Is there a relation between ART and DNA methylation (DNAm) patterns in cord blood, including any differences between IVF and ICSI? Summary [...]

By admin|2021-09-21T12:32:36+00:00September 20th, 2021|Papers epigenetica|0 Comments

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 |

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 | E Houtman, R Coutinho de Almeida, M Tuerlings, H E D Suchiman, D Broekhuis, R G H H Nelissen, Y F M Ramos, J B J van Meurs, I Meulenbelt Abstract Objective: We [...]

By admin|2021-11-09T11:57:47+00:00September 20th, 2021|Papers artrose|0 Comments

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology (Oxford, England) Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid [...]

By admin|2021-09-21T12:34:44+00:00September 20th, 2021|Papers artrose|0 Comments

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | February 2021 |Rheumatology and Therapy Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease, without effective disease-modifying treatment causing a large social and economic burden. In this study [...]

By admin|2021-09-21T12:34:56+00:00September 20th, 2021|Papers artrose|0 Comments

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