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The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies |February 2021|J Dev Orig Health Dis Emilie M Herzog 1, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Janine F Felix, Andrew P Stubbs, Peter J van der Spek, Joyce B J van Meurs, Bastiaan T Heijmans, Régine P M Steegers-Theunissen Abstract Epigenetic programming is essential [...]

By |2021-09-21T12:31:41+00:00September 20th, 2021|Papers epigenetica|0 Comments

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | E Clinical Medicine Sophie G.Groene, Jip A.Spekman, Arjan B.te Pas, Bastiaan T.Heijmans, Monique C.Haak, Jeanine M.M.van Klink, Arno A.W.Roest, Enrico Lopriore Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung [...]

By |2021-09-21T12:32:05+00:00September 20th, 2021|Papers epigenetica|0 Comments

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma, K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, I M Meulenbelt Abstract Introduction: Pathologically high growth hormone [...]

By |2021-09-21T12:33:58+00:00September 20th, 2021|Papers ageing, Papers artrose|0 Comments

DNA methylation differences at birth after conception through ART

DNA methylation differences at birth after conception through ART | January 2021 | Human Reproduction Elmar W Tobi, Catarina Almqvist, Anna Hedman, Ellika Andolf , Jan Holte, Jan I Olofsson, Håkan Wramsby, Margaretha Wramsby, Göran Pershagen, Bastiaan T Heijmans, Anastasia N Iliadou Abstract Study question: Is there a relation between ART and DNA methylation (DNAm) patterns in cord blood, including any differences between IVF and ICSI? Summary [...]

By |2021-09-21T12:32:36+00:00September 20th, 2021|Papers epigenetica|0 Comments

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 |

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 | E Houtman, R Coutinho de Almeida, M Tuerlings, H E D Suchiman, D Broekhuis, R G H H Nelissen, Y F M Ramos, J B J van Meurs, I Meulenbelt Abstract Objective: We [...]

By |2021-11-09T11:57:47+00:00September 20th, 2021|Papers artrose|0 Comments

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology (Oxford, England) Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid [...]

By |2021-09-21T12:34:44+00:00September 20th, 2021|Papers artrose|0 Comments

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | February 2021 |Rheumatology and Therapy Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease, without effective disease-modifying treatment causing a large social and economic burden. In this study [...]

By |2021-09-21T12:34:56+00:00September 20th, 2021|Papers artrose|0 Comments

How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

By |2021-11-09T13:19:14+00:00September 19th, 2021|News, Papers artrose|0 Comments

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | eclinicalmedicine Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias [...]

By |2021-09-15T13:37:03+00:00September 15th, 2021|Papers epigenetica|0 Comments
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