Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage | 2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]
Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | eclinicalmedicine Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias [...]
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink ... Show more Abstract Objective To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or [...]
Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers | 12-02-2020 | A Journal of Demography Niels van den Berg, Ingrid K. van Dijk, Rick J. Mourits, P. Eline Slagboom, Angelique A.P.O. Janssens & Kees Mandemakers Identifying genes that code for proteins associated to longevity is [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | 12-11-2020 | Leukemia Erik B. van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H. Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E. Jakobs, Daphne de Jong, P. Eline Slagboom, Frank J. T. Staal, Marcel J. T. Reinders & Henne Holstege Age-related Clonal hematopoiesis (ARCH) is an inevitable consequence of ageing, which arises when [...]
Prof. Eline Slagboom received the Karl Ludwig Schoberprice for leading ageing research. On Friday September 10th 2021 prof. Eline Slagboom received the Schober prize in Halle, Germany. Since 2003, the Karl Ludwig Schober Prize has been awarded every two years to renowned geriatric researchers. Karl-Ludwig Schober (July 13, 1912 – † October 11, 1999) was a German surgeon and professor [...]
Nature Genetics | September 6th 2021 Impact of genetics on epigenetics published in Nature Genetics Nature Genetics this week published the result of a major international study to chart the impact of genetics on DNA methylation, a key epigenetic mark. It was the result of an effort by more than 150 scientists of 50 [...]
NRC | 20 augustus 2021 | auteur Niki Korteweg Gezonde kinderen Een slechte start in de eerste duizend dagen na de conceptie zet een kind een leven lang op achterstand. Veel risicofactoren gaan samen: roken, drinken, stress… „Maar jonge kinderen hebben een enorme veerkracht.”\ Lees het artikel op de website van het NRC [...]
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida & Ingrid Meulenbelt Background Failing of intrinsic [...]
Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma | August 2021 | Haematologica Armando N. Bastidas Torres, Rutger C. Melchers, Liana van Grieken, Jacoba J. Out-Luiting, Hailiang Mei, Cedrick Agaser, Thomas B. Kuipers, Koen D. QuintRein Willemze, Maarten H. Vermeer, Cornelis P. Tensen Abstract Primary cutaneous anaplastic large cell lymphoma (pcALCL), a hematological neoplasm [...]
