Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation | September 2021 |Nature Genetics Josine L Min, Gibran Hemani, Eilis Hannon, Koen F Dekkers, Juan Castillo-Fernandez, René Luijk, ................................., Tom R Gaunt, Jordana T Bell, Bastiaan T Heijmans, Jonathan Mill, Caroline L Relton  Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and [...]

By |2021-09-21T12:27:34+00:00September 21st, 2021|Papers epigenetica|0 Comments

Effects of fatty acids on T cell function: role in atherosclerosis Nathalie A Reilly 1 2,

Effects of fatty acids on T cell function: role in atherosclerosis | July 2021 | Nat Rev Cardiol Nathalie A Reilly, Esther Lutgens, Johan Kuiper, Bastiaan T Heijmans, J Wouter Jukema Abstract T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. [...]

By |2021-09-21T12:29:03+00:00September 21st, 2021|Papers epigenetica|0 Comments

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence | March 2021 | Human Molecular Genetics Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman Abstract DNA [...]

By |2021-09-21T12:30:46+00:00September 21st, 2021|Papers epigenetica|0 Comments

Omixer: multivariate and reproducible sample randomization to proactively counter batch effects in omics studies

Omixer: multivariate and reproducible sample randomization to proactively counter batch effects in omics studies | March 2021 | Bioinformatics Lucy Sinke, Davy Cats, Bastiaan T Heijmans Abstract Motivation: Batch effects heavily impact results in omics studies, causing bias and false positive results, but software to control them preemptively is lacking. Sample randomization prior to measurement is vital [...]

By |2021-09-21T12:31:15+00:00September 20th, 2021|paper bioinformatica, Papers epigenetica|0 Comments

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies |February 2021|J Dev Orig Health Dis Emilie M Herzog 1, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Janine F Felix, Andrew P Stubbs, Peter J van der Spek, Joyce B J van Meurs, Bastiaan T Heijmans, Régine P M Steegers-Theunissen Abstract Epigenetic programming is essential [...]

By |2021-09-21T12:31:41+00:00September 20th, 2021|Papers epigenetica|0 Comments

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | E Clinical Medicine Sophie G.Groene, Jip A.Spekman, Arjan B.te Pas, Bastiaan T.Heijmans, Monique C.Haak, Jeanine M.M.van Klink, Arno A.W.Roest, Enrico Lopriore Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung [...]

By |2021-09-21T12:32:05+00:00September 20th, 2021|Papers epigenetica|0 Comments

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | eclinicalmedicine Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias [...]

By |2021-09-15T13:37:03+00:00September 15th, 2021|Papers epigenetica|0 Comments

Persistent epigenetic differences associated with prenatal exposure to famine in humans

Proc Natl Acad Sci USA | November 2009 Abstract Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to [...]

By |2021-07-20T08:37:25+00:00June 24th, 2021|Papers epigenetica|0 Comments
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