Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation | September 2021 |Nature Genetics Josine L Min, Gibran Hemani, Eilis Hannon, Koen F Dekkers, Juan Castillo-Fernandez, René Luijk, ................................., Tom R Gaunt, Jordana T Bell, Bastiaan T Heijmans, Jonathan Mill, Caroline L Relton  Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and [...]

Effects of fatty acids on T cell function: role in atherosclerosis | July 2021 | Nat Rev Cardiol Nathalie A Reilly, Esther Lutgens, Johan Kuiper, Bastiaan T Heijmans, J Wouter Jukema Abstract T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. [...]

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence | March 2021 | Human Molecular Genetics Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman Abstract DNA [...]

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies |February 2021|J Dev Orig Health Dis Emilie M Herzog 1, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Janine F Felix, Andrew P Stubbs, Peter J van der Spek, Joyce B J van Meurs, Bastiaan T Heijmans, Régine P M Steegers-Theunissen Abstract Epigenetic programming is essential [...]

Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM' | February 2021 | Nature reviews endocrinology Chihua Li, Elmar W Tobi, Bastiaan T Heijmans, L H Lumey 

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | E Clinical Medicine Sophie G.Groene, Jip A.Spekman, Arjan B.te Pas, Bastiaan T.Heijmans, Monique C.Haak, Jeanine M.M.van Klink, Arno A.W.Roest, Enrico Lopriore Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung [...]

Peter Thijssen| 01-09-2016 | Genetics and epigenetics of repeat derepression in human disease A large part of the human genome consists of repetitive DNA. In this thesis two human diseases have been studied in which deregulation of repetitive DNA is a central feature: facioscapulohumeral muscular dystrophy (FSHD) and immunodeficiency, centromere instability and facial anomalies [...]

Proc Natl Acad Sci USA | November 2009 Abstract Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to [...]