Niels van den Berg | 22-01-2020 | Family matters: a genealogical inquiry into the familial component of longevity Identifying genes that code for proteins associated to longevity is an important aspect of aging research. These longevity genes likely represent key mechanisms of a life-long decreased mortality and a decreased probability of age-related disease causing persons [...]

Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life was unexceptional. He was a farmer’s son and he worked [...]

René Luijk | 16-10-2019 |A Study into Genes Encoding Longevity in Humans In this thesis, we aimed to better understand how genetic variation affect the processes underlying health and disease, as trait-associated genetic variants are often located in non-coding regions. This hampers their interpretability, and has prompted the exploration of their effects on transcriptional [...]

Jesse Krijthe | 07-01-2018 | Robust semi-supervised learning: projections, limits & constraints In many domains of science and society, the amount of data being gathered is increasing rapidly. To estimate input-output relationships that are often of interest, supervised learning techniques rely on a specific type of data: labeled examples for which we know both [...]

Jonathan Vis | 21-12-2016 | Algorithms for the Description of Molecular Sequences Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society (HGVS) describes the observed variant sequence relative to a given reference sequence. We propose an efficient algorithm for the extraction of HGVS descriptions [...]