Nature Reviews Cardiology publiceerde een artikel over het effect van vetzuren op T cellen en de implicaties voor atherosclerose onder leiding van LUMC-onderzoekers Wouter Jukema (Cardiologie) en Bas Heijmans (Biomedische Datawetenschappen). ‘Het is hoog tijd voor meer aandacht voor T cellen in cardiovasculair onderzoek, want atherosclerotische plaques zitten vol onstekings en T cellen [...]
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells | July 2021 | Alejandro Rodríguez Ruiz, Amanda Dicks, Margo Tuerlings, Koen Schepers, Melissa van Pel, Rob G. H. H. Nelissen, Christian Freund, Christine L. Mummery, Valeria Orlova, Farshid Guilak, Ingrid Meulenbelt & Yolande F. M. Ramos [...]
Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome | July 2021 | Safa Najidh, Cornelis P Tensen, Alita J. van der Sluijs-Gelling, Cristina Teodosio, Davy Cats, Hailiang Mei, Thomas B. Kuipers, Jacoba J. Out-Luiting, Willem H. Zoutman, Thorbald van Hall, Alberto Orfao, Julia Almeida, Jacques J.M. J.M. van Dongen, Maarten H. Vermeer Key Points EuroFlow [...]
Niels van den Berg | 22-01-2020 | Family matters: a genealogical inquiry into the familial component of longevity Identifying genes that code for proteins associated to longevity is an important aspect of aging research. These longevity genes likely represent key mechanisms of a life-long decreased mortality and a decreased probability of age-related disease causing persons [...]
Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life was unexceptional. He was a farmer’s son and he worked [...]
René Luijk | 16-10-2019 |A Study into Genes Encoding Longevity in Humans In this thesis, we aimed to better understand how genetic variation affect the processes underlying health and disease, as trait-associated genetic variants are often located in non-coding regions. This hampers their interpretability, and has prompted the exploration of their effects on transcriptional [...]
Jennifer Meessen | 26-09-2019 | Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with [...]
Wouter den Hollander | 29-03-2018 | On the relation between genetic variation and osteoarthritis In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen [...]
Jesse Krijthe | 07-01-2018 | Robust semi-supervised learning: projections, limits & constraints In many domains of science and society, the amount of data being gathered is increasing rapidly. To estimate input-output relationships that are often of interest, supervised learning techniques rely on a specific type of data: labeled examples for which we know both [...]
Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first [...]
