Publicaties Artrose
A damaging COL6A3 variant alters the MIR31HG-regulated response of chondrocytes in neocartilage organoids to hyperphysiologic mechanical loading
A damaging COL6A3 variant alters the MIR31HG-regulated response of chondrocytes in neocartilage organoids to hyperphysiologic mechanical loading | January 2024 | Advanced Science NG Bloks, Z Harissa, G Mazzini, SS Adkar, AR Dicks, G Hajmousa, N Steward, RI Koning, A Mulder, BBR de Koning, [...]
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function [...]
Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in OA
R Coutinho de Almeida, M Tuerlings, YFM Ramos, W den Hollander, HED Suchiman, N Lakenberg, RGHH Nelissen, H Mei, I Meulenbelt | 30-04-2022 | Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in OA. Abstract Objectives To present an [...]
WWP2 confers risk to OA by affecting cartilage matrix deposition via hypoxia associated genes
WWP2 confers risk to OA by affecting cartilage matrix deposition via hypoxia associated genes| January 2023 | Osteoarthritis and Cartilage M Tuerlings, GMC Janssen, I Boone, M van Hoolwerff, A Rodriguez Ruiz, E Houtman, HED Suchiman, RJP van der Wal, RGHH Nelissen, R Coutinho [...]
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress | Osteoarthritis and Cartilage Open| 4(1) (2022) 100231 | doi: 10.1016/j.ocarto.2021.100231 R.G.M. Timmermans, N.G.C. Bloks, M. Tuerlings, M. van Hoolwerff, R.G.H.H. Nelissen, R.J.P. van der [...]
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis | Hum Mol Genet | 2022 Jan 28:ddac017 | doi: 10.1093/hmg/ddac017. Katsoula G, Steinberg J, Tuerlings M, de Almeida RC, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini [...]