Publicaties Artrose
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization Rheumatology (Oxford) | 2022 Apr 12:keac232 | doi: 10.1093/rheumatology/keac232 Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, [...]
The role of TNFRSF11B in development of osteoarthritic cartilage.
The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) | 2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease [...]
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, [...]
Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis GalleryAccepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid [...]
Fibronectin binding to collagen type II is crucial for articular chondrocytes to stay in a healthy steady state
Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer, KonstantinosHatzikotoulas, LorraineSoutham, LiljaStefánsdóttir, YanfeiZhang, RodrigoCoutinho de Almeida, Tian T.Wu, JieZheng, AprilHartley, MarisTeder-Lavin, Anne HeidiSkogholt, ChikashiTerao, EleniZengini, GeorgeAlexiadis AndreiBarysenka, GydaBjornsdottir, Maiken E.Gabrielsen, ArthurGilly…EleftheriaZeggini Osteoarthritis affects over 300 million people worldwide. [...]