Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the In the field of Osteoarthritis [...]

Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by pain, crepitus, and stiffness resulting in decreased mobility. Pathophysiology consists [...]

Steffan Bos | 15-09-2010 | Genes and Mediators of Inflammation and Development in Osteoarthritis Osteoarthritis (OA) mainly affects the articular cartilage covering the bones. In this thesis we investigated the relation between levels of inflammatory mediators, genes involved in their regulation and the disease [...]

Josine Min | 17-01-2007| Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease Osteoarthritis (OA) is a prevalent and complex disorder with a high hereditary probability. Previous genetic research into OA has yielded several common gene variants contributing to joint specific OA phenotypes. Only a few [...]

Naghmeh Riyazi | 22-11-2006 | Familial osteorarthritis : risk factors and determinants of outcome Osteoarthritis (OA) refers to a heterogeneous group of conditions. This thesis focuses on OA with a hereditary background; Familial OA at multiple joint sites and radiological hand OA at middle [...]