Nieuws2021-09-15T13:35:02+00:00

LAATSTE NIEUWS

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization Rheumatology (Oxford) | 2022 Apr 12:keac232 | doi: 10.1093/rheumatology/keac232 Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, Freund C, Mummery C, Everts V, de Vries TJ, Ramos [...]

april 19th, 2022|0 Comments

The role of TNFRSF11B in development of osteoarthritic cartilage.

The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) |  2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a complex genetic disease with different risk factors contributing to its development. One of [...]

april 19th, 2022|0 Comments

Leidse masterstudent kraakt epigenetische klok die leeftijd voorspelt – nieuwsbericht LUMC 14-01-2022

Onderzoekers kunnen aan de hand van de afstelling van het DNA nauwkeurig vaststellen hoe oud iemand is. Daarvoor gebruiken ze een zogeheten epigenetische klok. Masterstudent Thomas Jonkman heeft nu, negen jaar na de ontdekking, ontrafeld hoe deze klok precies werkt: het blijkt de veroudering van ons immuunsysteem bij te houden. Met deze kennis kan [...]

januari 17th, 2022|0 Comments

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma,  H. Eka D. Suchiman, Roman I. Koning, Carolina R. Jost, Aat A. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos and Ingrid [...]

november 9th, 2021|0 Comments

Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt Abstract Objective To gain insight in the expression profile [...]

november 9th, 2021|0 Comments

Fibronectin binding to collagen type II is crucial for articular chondrocytes to stay in a healthy steady state

Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. Upon introducing this mutation in an in vitro OA disease model using human [...]

november 9th, 2021|0 Comments
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