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Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection GalleryComparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Giorgia Mazzini, Margo Tuerlings,[...], and Ingrid Meulenbelt | 08-06-2026 | Cell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production by hiPSC-derived chondroprogenitors (hiCPCs), their derived chondrocytes (hiCHOs), and primary articular chondrocytes (hACs) [...]
ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline
Swier Garst,[...], P Eline Slagboom, Joyce van Meurs | 18-05-2026 | Because individuals age at different rates, robust aging biomarkers are needed beyond chronological age. However, the methodological choices that shape such biomarkers have not been compared in a unified framework. This study addresses that gap by evaluating model choice, training targets, and protein [...]