Interactions of cognitive and physical ageing
Marjon Stijntjes | 12-10-2016 |A Study into Genes Encoding Longevity in Humans Human ageing is characterized by a gradual decline in cognitive and physical performance strongly determining someone’s functional abilities and quality of life. [...]
Genetics and epigenetics of repeat derepression in human disease
Peter Thijssen| 01-09-2016 | Genetics and epigenetics of repeat derepression in human disease A large part of the human genome consists of repetitive DNA. In this thesis two human diseases have been studied in [...]
Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA
Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by [...]
(Epi) genetics and twins
Jenny van Dongen | 16-04-2015 | (Epi)genetics and twins The research described in this thesis was characterized by two major themes: the first was related to the question to which extent variation between individuals [...]
Computational Biology in Human Aging. An omics data integration approach
Erik van den Akker | 28-02-2015 | Computational Biology in Human Aging. An omics data integration approach Throughout this thesis, human aging and its relation to health are studied in the context of two [...]
Studies into epigenetic variation and its contribution to cardiovascular disease
Rudolf Talens | 08-01-2015 |Studies into epigenetic variation and its contribution to cardiovascular disease Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully [...]