The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | British society for Rheumatology Alejandro Rodríguez Ruiz, Margo Tuerlings, Ankita Das, Rodrigo Coutinho de Almeida, H Eka Suchiman, Rob G H H Nelissen, Yolande F M Ramos, Ingrid Meulenbelt Abstract Objectives Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the [...]
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology (Oxford, England) Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid [...]
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | February 2021 |Rheumatology and Therapy Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease, without effective disease-modifying treatment causing a large social and economic burden. In this study [...]
Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma , K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, and I M Meulenbelt Abstract Introduction Pathologically high growth hormone [...]
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | 20-02-2021 | Rheumatology and Therapy Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H. D. Suchiman, Enrike van der Linden-van der Zwaag, Rob G. H. H. Nelissen, Yolande F. M. Ramos & Ingrid Meulenbelt Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) [...]
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida & Ingrid Meulenbelt Background Failing of intrinsic [...]
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations | September 2021 | Cell Cindy G.Boer147KonstantinosHatzikotoulas247LorraineSoutham247LiljaStefánsdóttir3YanfeiZhang4RodrigoCoutinho de Almeida5Tian T.Wu6JieZheng7AprilHartley78MarisTeder-Laving9Anne HeidiSkogholt10ChikashiTerao11EleniZengini12GeorgeAlexiadis13AndreiBarysenka2GydaBjornsdottir3Maiken E.Gabrielsen10ArthurGilly2…EleftheriaZeggini24648 Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of [...]
Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers | Biomolecules| 13-09-2021 | Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Nico Lakenberg, H. Eka D. Suchiman, Hailiang Mei, Margreet Kloppenburg, Rob G. H. H. Nelissen and Ingrid Meulenbelt To identify and validate circulating micro [...]
