Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis

Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis | August 2021 | The Journal of Pathology Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter Ten Dijke  Abstract Chondrocytes in mice developing osteoarthritis (OA) exhibit an aberrant response to the secreted cytokine transforming [...]

Door |2021-09-21T10:46:21+00:00september 21st, 2021|Papers artrose|0 Reacties

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets | May 2021 | Arthritis Rheumatology Margo Tuerlings, Marcella van Hoolwerff, Evelyn Houtman, Eka H E D Suchiman, Nico Lakenberg, Hailiang Mei, Enrike H M J van der Linden, Rob R G H H Nelissen, Yolande Y F [...]

Door |2021-09-21T09:09:52+00:00september 21st, 2021|Papers artrose, Papers artrose|0 Reacties

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | March 2021 | Rheumatology and Therapy Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H. D. Suchiman, Enrike van der Linden-van der Zwaag, Rob G. H. H. Nelissen, Yolande F. M. Ramos & Ingrid Meulenbelt Abstract Introduction Likely [...]

Door |2021-09-21T10:57:53+00:00september 21st, 2021|Papers artrose, Papers artrose|0 Reacties

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma, K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, I M Meulenbelt Abstract Introduction: Pathologically high growth hormone [...]

Door |2021-09-22T07:52:23+00:00september 20th, 2021|Papers ageing, Papers artrose|0 Reacties

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 |

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin | August 2021 | E Houtman, R Coutinho de Almeida, M Tuerlings, H E D Suchiman, D Broekhuis, R G H H Nelissen, Y F M Ramos, J B J van Meurs, I Meulenbelt Abstract Objective: We [...]

Door |2021-11-09T11:51:49+00:00september 20th, 2021|Papers artrose|0 Reacties

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology (Oxford, England) Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid [...]

Door |2021-09-20T07:40:24+00:00september 20th, 2021|Papers artrose, Papers artrose|0 Reacties

How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

Door |2021-11-09T11:37:32+00:00september 19th, 2021|Nieuws, Papers artrose|0 Reacties

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers | Biomolecules| 13-09-2021 |  Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Nico Lakenberg, H. Eka D. Suchiman, Hailiang Mei, Margreet Kloppenburg, Rob G. H. H. Nelissen and Ingrid Meulenbelt To identify and validate circulating micro [...]

Door |2021-09-14T12:26:42+00:00september 14th, 2021|Papers artrose|0 Reacties

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida & Ingrid Meulenbelt Background Failing of intrinsic [...]

Door |2021-11-09T11:47:13+00:00augustus 15th, 2021|Nieuws, Papers artrose|0 Reacties

Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells

Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells | July 2021 | Alejandro Rodríguez Ruiz, Amanda Dicks, Margo Tuerlings, Koen Schepers, Melissa van Pel, Rob G. H. H. Nelissen, Christian Freund, Christine L. Mummery, Valeria Orlova, Farshid Guilak, Ingrid Meulenbelt & Yolande F. M. Ramos [...]

Door |2021-11-09T11:44:51+00:00juli 20th, 2021|Papers artrose|0 Reacties
Ga naar de bovenkant