Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells | July 2021 | Alejandro Rodríguez Ruiz, Amanda Dicks, Margo Tuerlings, Koen Schepers, Melissa van Pel, Rob G. H. H. Nelissen, Christian Freund, Christine L. Mummery, Valeria Orlova, Farshid Guilak, Ingrid Meulenbelt & Yolande F. M. Ramos [...]

Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls |  Clin exp Rheumothol | May/June 2021 Marije K Verheul, George M C Janssen, Arnoud de Ru, Gerrie Stoeken-Rijsbergen, E W Nivine Levarht, Joanneke C Kwekkeboom, Nils Bomer, Andreea Ioan-Facsinay, Ingrid Meulenbelt, Robert A Cordfunke, Jan W Drijfhout, Rene E M Toes, Peter A van Veelen, Leendert A Trouw Abstract Objectives: Antibodies targeting [...]

The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | Annals of the Rheumatic diseases Cindy G Boer, Ingrid Szilagyi, N Long Nguyen, Tuhina Neogi, Ingrid Meulenbelt, M Arfan Ikram, André G Uitterlinden, Sita Bierma-Zeinstra, Bruno H Stricker, Joyce B van Meurs Correspondence to Dr Joyce B van Meurs, Internal Medicine, Erasmus Medical Center, [...]

The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | Rheumatology (Oxford) Alejandro Rodríguez Ruiz, Margo Tuerlings, Ankita Das, Rodrigo Coutinho de Almeida, H Eka Suchiman, Rob G H H Nelissen, Yolande F M Ramos, Ingrid Meulenbelt Abstract Objectives Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously [...]

Censoring exosomal crosstalk in osteoarthritis |April 15 2021 | Nature Aging Ingrid Meulenbelt, Yolande F. M. Ramos, S. Rubina Baglio & D. Michiel Pegtel Abstract Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor [...]

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies | January 26 2021 | Addiction Biology Melissa A Munn-Chernoff, Emma C Johnson, Yi-Ling Chou, Jonathan R I Coleman, Laura M Thornton, ..................(including Meulenbelt I) Neale BM, Gerome Breen, Joel Gelernter, Howard J Edenberg, Cynthia M Bulik, Arpana Agrawal Abstract Eating disorders and substance use disorders frequently co-occur. [...]

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma , K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, and I M Meulenbelt Abstract Introduction Pathologically high growth hormone [...]