Papers Bio-Informatics
Beyond the CpG: an integrative approach to decoding DNA methylation in immunometabolic health
Lucy Sinke | 07-05-2026 | Beyond the CpG: an integrative approach to decoding DNA methylation in immunometabolic health Epigenetics as a key to healthier ageing Why do we slow down, gain weight, and become more vulnerable to disease as we age? [...]
Application of human induced pluripotent stem cells for tissue modeling and therapy: are we on track?
Nickel Maunu M, Meulenbelt I, Ramos YFM | 22-07-2026 | Stem cells are key for development of disease modeling and therapies. While promising, however, current application of cutting-edge hiPSC technologies is, among others, confounded by cellular heterogeneity leading to concerns about [...]
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection GalleryComparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection
Giorgia Mazzini, Margo Tuerlings,[...], and Ingrid Meulenbelt | 08-06-2026 | Cell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production [...]
ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline
Swier Garst,[...], P Eline Slagboom, Joyce van Meurs | 18-05-2026 | Because individuals age at different rates, robust aging biomarkers are needed beyond chronological age. However, the methodological choices that shape such biomarkers have not been compared in a unified framework. [...]
Development of innovative therapeutic strategies for osteoarthritis: exploring thermosensitive hydrogels, hiPSC-derived cells and cell-products, and novel drugs in preclinical models GalleryDevelopment of innovative therapeutic strategies for osteoarthritis: exploring thermosensitive hydrogels, hiPSC-derived cells and cell-products, and novel drugs in preclinical models
Development of innovative therapeutic strategies for osteoarthritis: exploring thermosensitive hydrogels, hiPSC-derived cells and cell-products, and novel drugs in preclinical models
Sana Sayedipour | 07-05-2026 | Development of innovative therapeutic strategies for osteoarthritis: exploring thermosensitive hydrogels, hiPSC-derived cells and cell-products, and novel drugs in preclinical models This thesis focuses on developing innovative therapeutic strategies for osteoarthritis (OA), a prevalent and disabling joint [...]
Nuclear Factor I genes drive chondrogenic cell-fate commitment
Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from [...]