Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology (Oxford, England) Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid [...]

By |2021-09-21T12:34:44+00:00September 20th, 2021|Papers artrose|0 Comments
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Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | February 2021 |Rheumatology and Therapy Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease, without effective disease-modifying treatment causing a large social and economic burden. In this study [...]

By |2021-09-21T12:34:56+00:00September 20th, 2021|Papers artrose|0 Comments
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How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 Sep 29 | S1063-4584(21)00915-8. doi: 10.1016/j.joca.2021.09.010. Abstract Hip and knee [...]

By |2021-11-09T13:19:14+00:00September 19th, 2021|News, Papers artrose|0 Comments
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Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins | February 2021 | eclinicalmedicine Abstract Background Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias [...]

By |2021-09-15T13:37:03+00:00September 15th, 2021|Papers epigenetica|0 Comments
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Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration | March 2021 | Rheumatology Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink ... Show more Abstract Objective To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or [...]

By |2021-09-21T12:35:43+00:00September 15th, 2021|Papers artrose|0 Comments
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Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers

Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers | 12-02-2020 | A Journal of Demography Niels van den Berg, Ingrid K. van Dijk, Rick J. Mourits, P. Eline Slagboom, Angelique A.P.O. Janssens & Kees Mandemakers Identifying genes that code for proteins associated to longevity is [...]

By |2021-09-14T14:48:58+00:00September 14th, 2021|Papers ageing|0 Comments
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Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | 12-11-2020 | Leukemia Erik B. van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H. Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E. Jakobs, Daphne de Jong, P. Eline Slagboom, Frank J. T. Staal, Marcel J. T. Reinders & Henne Holstege Age-related Clonal hematopoiesis (ARCH) is an inevitable consequence of ageing, which arises when [...]

By |2021-09-21T12:35:16+00:00September 14th, 2021|Papers ageing, Uncategorized|0 Comments
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Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers | Biomolecules| 13-09-2021 |  Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Nico Lakenberg, H. Eka D. Suchiman, Hailiang Mei, Margreet Kloppenburg, Rob G. H. H. Nelissen and Ingrid Meulenbelt To identify and validate circulating micro [...]

By |2021-09-14T14:30:54+00:00September 14th, 2021|Papers artrose|0 Comments
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Prize for prof. Eline Slagboom

Prof. Eline Slagboom received the Karl Ludwig Schoberprice for leading ageing research. On Friday September 10th 2021 prof. Eline Slagboom received the Schober prize in Halle, Germany. Since 2003, the Karl Ludwig Schober Prize has been awarded every two years to renowned geriatric researchers. Karl-Ludwig Schober (July 13, 1912 – † October 11, 1999) was a German surgeon and professor [...]

By |2021-09-13T08:43:05+00:00September 13th, 2021|News|0 Comments
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Impact of genetics on epigenetics published in Nature Genetics – September 6th 2021

Nature Genetics | September 6th 2021 Impact of genetics on epigenetics published in Nature Genetics Nature Genetics this week published the result of a major international study to chart the impact of genetics on DNA methylation, a key epigenetic mark. It was the result of an effort by more than 150 scientists of 50 [...]

By |2021-09-10T12:45:49+00:00September 10th, 2021|News, Papers epigenetica|0 Comments
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Moleculaire Epidemiologie  | copyright 2021

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