Theses ageing
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Proc Natl Acad Sci USA | November 2009 Abstract Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. [...]
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
Epigenetics & Chromatin | Volume 6 | article numebr 26 | 06 August 2013 Abstract DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in [...]
Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls
Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls | Clin exp Rheumothol | May/June 2021 Marije K Verheul, George M C Janssen, Arnoud de Ru, Gerrie Stoeken-Rijsbergen, E W Nivine Levarht, Joanneke C Kwekkeboom, Nils Bomer, Andreea Ioan-Facsinay, Ingrid Meulenbelt, Robert A Cordfunke, Jan W Drijfhout, Rene E [...]
Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis
The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | Annals of the Rheumatic diseases Cindy G Boer, Ingrid Szilagyi, N Long Nguyen, Tuhina Neogi, Ingrid Meulenbelt, M Arfan Ikram, André G Uitterlinden, Sita Bierma-Zeinstra, Bruno H Stricker, Joyce B van Meurs Correspondence [...]
The role of TNFRSF11B in development of osteoarthritic cartilag
The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | Rheumatology (Oxford) Alejandro Rodríguez Ruiz, Margo Tuerlings, Ankita Das, Rodrigo Coutinho de Almeida, H Eka Suchiman, Rob G H H Nelissen, Yolande F M Ramos, Ingrid Meulenbelt Abstract Objectives Osteoarthritis (OA) is a complex genetic disease with different risk [...]
Censoring exosomal crosstalk in osteoarthritis
Censoring exosomal crosstalk in osteoarthritis |April 15 2021 | Nature Aging Ingrid Meulenbelt, Yolande F. M. Ramos, S. Rubina Baglio & D. Michiel Pegtel Abstract Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to [...]