Theses ageing
Genetic Determinants of Healthy Longevity
Simon Mooijaart| 04-12-2007 | Genetic Determinants of Healthy Longevity Lifespan in under genetic control. In this thesis we translated genes regulating lifespan in model organisms to humans. First we identified DAF-12 as a critical gene for lifespan regulation in the nematode worm C. elegans. [...]
A Study into Genes Encoding Longevity in Humans
Maris Kuningas | 04-12-2007 |A Study into Genes Encoding Longevity in Humans The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the wide variability in lifespan between and within species. In [...]
Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease
Josine Min | 17-01-2007| Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease Osteoarthritis (OA) is a prevalent and complex disorder with a high hereditary probability. Previous genetic research into OA has yielded several common gene variants contributing to joint specific OA phenotypes. Only a few [...]
Familial osteorarthritis : risk factors and determinants of outcome
Naghmeh Riyazi | 22-11-2006 | Familial osteorarthritis : risk factors and determinants of outcome Osteoarthritis (OA) refers to a heterogeneous group of conditions. This thesis focuses on OA with a hereditary background; Familial OA at multiple joint sites and radiological hand OA at middle [...]
Osteoarthritis and hemochromatosis, a genetic epidemiological study
B.Z. Alizadeh (Behrooz)| 23-03-2005 | Osteoarthritis and hemochromatosis, a genetic epidemiological study Osteoarthritis (OA) refers to a heterogeneous group of distinct diseases which express a common radiographic and clinical phenotype at diarthrodial joints.It is the leading cause of pain and disability in the [...]
Prestigious ZonMw Open Competition grant awarded to LUMC, VU and RIVM
Prestigious ZonMw Open Competition grant awarded to LUMC, Vu and RIVM Our life expectancy is increasing worldwide, but the years we spend in good health are lagging behind. People from long-lived families often reach exceptionally old ages without disease. How is that [...]