Censoring exosomal crosstalk in osteoarthritis |April 15 2021 | Nature Aging
Ingrid Meulenbelt, Yolande F. M. Ramos, S. Rubina Baglio & D. Michiel Pegtel
Abstract
Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.