Theses ageing
Nature Reviews Cardiology publication about T cells in atherosclerosis
Nature Reviews Cardiology publiceerde een artikel over het effect van vetzuren op T cellen en de implicaties voor atherosclerose onder leiding van LUMC-onderzoekers Wouter Jukema (Cardiologie) en Bas Heijmans (Biomedische Datawetenschappen). ‘Het is hoog tijd voor meer aandacht voor T cellen in cardiovasculair [...]
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells | July 2021 | Alejandro Rodríguez Ruiz, Amanda Dicks, Margo Tuerlings, Koen Schepers, Melissa van Pel, Rob G. H. H. Nelissen, Christian Freund, Christine L. Mummery, Valeria [...]
Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome
Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome | July 2021 | Safa Najidh, Cornelis P Tensen, Alita J. van der Sluijs-Gelling, Cristina Teodosio, Davy Cats, Hailiang Mei, Thomas B. Kuipers, Jacoba J. Out-Luiting, Willem H. Zoutman, Thorbald van Hall, Alberto Orfao, Julia [...]
Family matters: a genealogical inquiry into the familial component of longevity
Niels van den Berg | 22-01-2020 | Family matters: a genealogical inquiry into the familial component of longevity Identifying genes that code for proteins associated to longevity is an important aspect of aging research. These longevity genes likely represent key mechanisms of a life-long decreased [...]
Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries
Rick Mourits | 17-12-2019 | Exceptional lives, extraordinary families. Familial clustering of longevity in the 19th and early-20th centuries On 4 October 1829, Leendert Wisse was born in Meliskerke, a small, rural town on the island of Walcheren in Zeeland. In many ways, Leendert’s life [...]
From correlation to causation: Data-driven exploration of transcriptional regulation using population genomics
René Luijk | 16-10-2019 |A Study into Genes Encoding Longevity in Humans In this thesis, we aimed to better understand how genetic variation affect the processes underlying health and disease, as trait-associated genetic variants are often located in non-coding regions. This hampers their interpretability, [...]