Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations

Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations | Genes Immun | July 2021 Khatri I, Berkowska MA, van den Akker EB, Teodosio C, Reinders MJT, van Dongen JJM. Abstract Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity [...]

Door |2021-09-27T08:54:53+00:00september 27th, 2021|paper bioinformatica, Papers ageing|0 Reacties

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020 van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Age-related Clonal hematopoiesis (ARCH) is an inevitable [...]

Door |2021-09-27T08:47:21+00:00september 27th, 2021|paper bioinformatica, Papers ageing|0 Reacties

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian  | July 2021 | Leukemia Erik B van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E Jakobs, Daphne de Jong, P Eline Slagboom, Frank J T Staal, Marcel J T Reinders, Henne Holstege  Link to whole paper

Door |2021-09-21T10:01:54+00:00september 21st, 2021|Papers ageing|0 Reacties

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study  | June 2021 | Geroscience Maria Giulia Bacalini, Anna Reale, Marco Malavolta, Fabio Ciccarone, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Miriam Capri, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Nicolle Breusing, Valentina Aversano, Stefano Tagliatesta, Claudio Franceschi, Maria A Blasco, Alexander [...]

Door |2021-09-21T09:41:29+00:00september 21st, 2021|Papers ageing|0 Reacties

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study | June 2021 | Metabolomics Wenyi Wang, Ko Willems van Dijk, Carolien A Wijsman, Maarten P Rozing, Simon P Mooijaart, Marian Beekman, P Eline Slagboom, J Wouter Jukema, Raymond Noordam, Diana van Heemst Abstract Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin [...]

Door |2021-09-21T09:35:02+00:00september 21st, 2021|Papers ageing|0 Reacties

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | May 2021 | Elife Heli Julkunen, Anna Cichońska, P Eline Slagboom  , Peter Würtz, Nightingale Health UK Biobank Initiative Abstract Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to [...]

Door |2021-09-21T09:28:49+00:00september 21st, 2021|Papers ageing|0 Reacties

Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study

Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study  | May 2021 | J Gerontol A Biol Sci Med Sci Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Andrea Basso, Alexander Bürkle, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix [...]

Door |2021-09-21T09:20:36+00:00september 21st, 2021|Papers ageing|0 Reacties

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains | March 2021 | Scientific Reports L Kananen, L Enroth, J Raitanen, J Jylhävä, A Bürkle, M Moreno-Villanueva, J Bernhardt, O Toussaint, B Grubeck-Loebenstein, M Malavolta, A Basso, F Piacenza, S Collino, E S Gonos, E Sikora, D Gradinaru  E H J M Jansen, M E T Dollé, M Salmon, W Stuetz D , Weber, T [...]

Door |2021-09-21T11:52:10+00:00september 21st, 2021|Papers ageing|0 Reacties

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Correction for both common and rare cell types in blood is important to identify genes that correlate with age | March 2021 | BMC Genomics Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, BIOS Consortium, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra & Lude Franke Abstract BACKGROUND: Aging is a multifactorial process that [...]

Door |2021-09-21T08:40:27+00:00september 21st, 2021|Papers ageing, Papers ageing|0 Reacties

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults | February 2021 | The Journal of Infectious Diseases Sijia Chen, Graham Pawelec, Stella Trompet, David Goldeck, Laust H. Mortensen, P. Eline Slagboom, Kaare Christensen, Jacobijn Gussekloo, Patricia Kearney, Brendan M. Buckley, Ian Ford, J. Wouter Jukema, Rudi G.J. Westendorp, Andrea B. [...]

Door |2021-09-20T09:01:16+00:00september 20th, 2021|Papers ageing, Papers ageing|0 Reacties
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