The trans-ancestral genomic architecture of glycemic traits | Nat Genet | June 2021 Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, …, Erik van den Akker, …, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A. Abstract Glycemic traits are used to diagnose and monitor type [...]
Discovering fiber type architecture over the entire muscle using data-driven analysis | June 2021 | Cytometry A Bindellini D, Voortman LM, Olie Cyriel S, van Putten M, van den Akker EB, Raz V. Abstract Skeletal muscle function is inferred from the spatial arrangement of muscle fiber architecture, which corresponds to myofiber molecular and metabolic [...]
Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations | Genes Immun | July 2021 Khatri I, Berkowska MA, van den Akker EB, Teodosio C, Reinders MJT, van Dongen JJM. Abstract Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020 van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Age-related Clonal hematopoiesis (ARCH) is an inevitable [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia Erik B van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E Jakobs, Daphne de Jong, P Eline Slagboom, Frank J T Staal, Marcel J T Reinders, Henne Holstege Link to whole paper
Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study | June 2021 | Geroscience Maria Giulia Bacalini, Anna Reale, Marco Malavolta, Fabio Ciccarone, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Miriam Capri, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Nicolle Breusing, Valentina Aversano, Stefano Tagliatesta, Claudio Franceschi, Maria A Blasco, Alexander [...]
Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study | June 2021 | Metabolomics Wenyi Wang, Ko Willems van Dijk, Carolien A Wijsman, Maarten P Rozing, Simon P Mooijaart, Marian Beekman, P Eline Slagboom, J Wouter Jukema, Raymond Noordam, Diana van Heemst Abstract Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin [...]
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | May 2021 | Elife Heli Julkunen, Anna Cichońska, P Eline Slagboom , Peter Würtz, Nightingale Health UK Biobank Initiative Abstract Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to [...]
Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study | May 2021 | J Gerontol A Biol Sci Med Sci Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Andrea Basso, Alexander Bürkle, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix [...]
Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains | March 2021 | Scientific Reports L Kananen, L Enroth, J Raitanen, J Jylhävä, A Bürkle, M Moreno-Villanueva, J Bernhardt, O Toussaint, B Grubeck-Loebenstein, M Malavolta, A Basso, F Piacenza, S Collino, E S Gonos, E Sikora, D Gradinaru E H J M Jansen, M E T Dollé, M Salmon, W Stuetz D , Weber, T [...]
