Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020
van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H.
Age-related Clonal hematopoiesis (ARCH) is an inevitable consequence of ageing, which arises when an ageing hematopoietic stem cell (HSC) acquires a somatic mutation that confers a competitive growth advantage, leading to its gradual expansion . ARCH-associated mutations typically target genes associated with acute myeloid leukemia, most frequently the epigenetic regulators DNMT3A and TET2 . When a substantial proportion of the blood cells carries such a pre-leukemic mutation in an otherwise normal immuno-hematopoietic system, this state is also referred to as Clonal Hematopoiesis of Indeterminate Potential .
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