Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study  | June 2021 | Geroscience Maria Giulia Bacalini, Anna Reale, Marco Malavolta, Fabio Ciccarone, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Miriam Capri, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Nicolle Breusing, Valentina Aversano, Stefano Tagliatesta, Claudio Franceschi, Maria A Blasco, Alexander [...]

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study | June 2021 | Metabolomics Wenyi Wang, Ko Willems van Dijk, Carolien A Wijsman, Maarten P Rozing, Simon P Mooijaart, Marian Beekman, P Eline Slagboom, J Wouter Jukema, Raymond Noordam, Diana van Heemst Abstract Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin [...]

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population | May 2021 | Elife Heli Julkunen, Anna Cichońska, P Eline Slagboom  , Peter Würtz, Nightingale Health UK Biobank Initiative Abstract Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to [...]

Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study  | May 2021 | J Gerontol A Biol Sci Med Sci Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Andrea Basso, Alexander Bürkle, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix [...]

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains | March 2021 | Scientific Reports L Kananen, L Enroth, J Raitanen, J Jylhävä, A Bürkle, M Moreno-Villanueva, J Bernhardt, O Toussaint, B Grubeck-Loebenstein, M Malavolta, A Basso, F Piacenza, S Collino, E S Gonos, E Sikora, D Gradinaru  E H J M Jansen, M E T Dollé, M Salmon, W Stuetz D , Weber, T [...]

Correction for both common and rare cell types in blood is important to identify genes that correlate with age | March 2021 | BMC Genomics Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, BIOS Consortium, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra & Lude Franke Abstract BACKGROUND: Aging is a multifactorial process that [...]