The trans-ancestral genomic architecture of glycemic traits | Nat Genet | June 2021 Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, …, Erik van den Akker, …, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A. Abstract Glycemic traits are used to diagnose and monitor type [...]
Discovering fiber type architecture over the entire muscle using data-driven analysis | June 2021 | Cytometry A Bindellini D, Voortman LM, Olie Cyriel S, van Putten M, van den Akker EB, Raz V. Abstract Skeletal muscle function is inferred from the spatial arrangement of muscle fiber architecture, which corresponds to myofiber molecular and metabolic [...]
Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations | Genes Immun | July 2021 Khatri I, Berkowska MA, van den Akker EB, Teodosio C, Reinders MJT, van Dongen JJM. Abstract Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia. 2020 van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Age-related Clonal hematopoiesis (ARCH) is an inevitable [...]
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation | September 2021 |Nature Genetics Josine L Min, Gibran Hemani, Eilis Hannon, Koen F Dekkers, Juan Castillo-Fernandez, René Luijk, ................................., Tom R Gaunt, Jordana T Bell, Bastiaan T Heijmans, Jonathan Mill, Caroline L Relton Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and [...]
Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis | August 2021 | JAMA Internal Medicin Nicolien A van Vliet, Diana van Heemst, Osvaldo P Almeida, Bjørn O Åsvold, Carole E Aubert, Jong Bin Bae, Linda E Barnes, Douglas C Bauer, Gerard J Blauw, Carol Brayne, Anne R Cappola, Graziano Ceresini, Hannie C Comijs , Jean-Francois Dartigues ,Jean-Marie Degryse , Robin P F Dullaart, Marlise E A van Eersel [...]
Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis | August 2021 | The Journal of Pathology Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter Ten Dijke Abstract Chondrocytes in mice developing osteoarthritis (OA) exhibit an aberrant response to the secreted cytokine transforming [...]
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | July 2021 | Leukemia Erik B van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E Jakobs, Daphne de Jong, P Eline Slagboom, Frank J T Staal, Marcel J T Reinders, Henne Holstege Link to whole paper
Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study | July 2021 | Frontiers in Microbiology Patrizia D'Aquila, Robertina Giacconi, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune , Efstathios S Gonos, Claudio Franceschi, Miriam Capri, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P Eline Slagboom, Christiane Schön, Jürgen Bernhardt, Nicolle Breusing, Giuseppe Passarino, Mauro Provinciali , Dina Bellizzi [...]
Effects of fatty acids on T cell function: role in atherosclerosis | July 2021 | Nat Rev Cardiol Nathalie A Reilly, Esther Lutgens, Johan Kuiper, Bastiaan T Heijmans, J Wouter Jukema Abstract T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. [...]
