Robust semi-supervised learning: projections, limits & constraints
Jesse Krijthe | 07-01-2018 | Robust semi-supervised learning: projections, limits & constraints In many domains of science and society, the amount of data being gathered is increasing rapidly. To estimate input-output relationships that are [...]
Charting the dynamic methylome across the human lifespan
Roderik Slieker | 09-02-2017 | Charting the dynamic methylome across the human lifespan In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing [...]
Thyroid hormone signalling in Osteoarthritis: early life events in late life disease
Niels Bömer | 17-01-2017 | Thyroid hormone signalling in Osteoarthritis: early life events in late life disease The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of [...]
Algorithms for the Description of Molecular Sequences
Jonathan Vis | 21-12-2016 | Algorithms for the Description of Molecular Sequences Unambiguous sequence variant descriptions are important in reporting the outcome of clinical diagnostic DNA tests. The standard nomenclature of the Human Genome Variation Society [...]
Interactions of cognitive and physical ageing
Marjon Stijntjes | 12-10-2016 |A Study into Genes Encoding Longevity in Humans Human ageing is characterized by a gradual decline in cognitive and physical performance strongly determining someone’s functional abilities and quality of life. [...]
Genetics and epigenetics of repeat derepression in human disease
Peter Thijssen| 01-09-2016 | Genetics and epigenetics of repeat derepression in human disease A large part of the human genome consists of repetitive DNA. In this thesis two human diseases have been studied in [...]