Proefschriften Ageing2021-07-20T08:16:33+00:00

Proefschriften ageing

Computational Biology in Human Aging. An omics data integration approach

Erik van den Akker | 28-02-2015 | Computational Biology in Human Aging. An omics data integration approach Throughout this thesis, human aging and its relation to health are studied in the context of two parallel though complementary lines of research: biomarkers and genetics. The [...]

juli 5th, 2021|Categories: proefschrift ageing|

Genetic and biomarker studies of human longevity

Joris Deelen |25-06-2014 | Genetic and biomarker studies of human longevity  The aim of this thesis was to identify novel lifespan regulating loci that influence human longevity and population mortality. To this end, we performed two genome-wide association studies, one of long-lived individuals from [...]

juli 5th, 2021|Categories: proefschrift ageing|

Endocrine and metabolic features of familial longevity The Leiden Longevity Study

Maarten Rozing| 21-09-2011 | Endocrine and metabolic features of familial longevity The Leiden Longevity Study This thesis discusses the metabolic and endocrine characteristics of long-lived Dutch families. We found that familial longevity is marked by low thyroid function and preserved insulin senitivity. The second [...]

juli 5th, 2021|Categories: proefschrift ageing|

Genetic determinants of eating disorders

Rita Slof-Op 't Landt| 04-12-2007 | Genetic determinants of eating disorders In this thesis, a series of studies on different aspects of the genetics of eating disorders is presented. The heritability of disordered eating behavior and attitudes in relation with body mass index (BMI) [...]

juli 5th, 2021|Categories: proefschrift ageing|

Glycomics based biomarkers of the rate of aging: Development and applications of high throughput N-glycan analysis

Renée Ruhaak | 24-03-2011 | Glycomics based biomarkers of the rate of aging: Development and applications of high throughput N-glycan analysis Markers for longevity, which reflect the health condition and predict healthspan are extremely scarce. Such markers are, however, valuable in aging research. Protein [...]

juli 5th, 2021|Categories: proefschrift ageing|

Genetic Determinants of Healthy Longevity

Simon Mooijaart| 04-12-2007 | Genetic Determinants of Healthy Longevity Lifespan in under genetic control. In this thesis we translated genes regulating lifespan in model organisms to humans. First we identified DAF-12 as a critical gene for lifespan regulation in the nematode worm C. elegans. [...]

juli 5th, 2021|Categories: proefschrift ageing|
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